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1
Regulation of sugar transport via the multiple sugar metabolism operon of Streptococcus mutans by the phosphoenolpyruvate phosphotransferase system.通过磷酸烯醇式丙酮酸磷酸转移酶系统对变形链球菌多种糖代谢操纵子介导的糖转运进行调控。
J Bacteriol. 1995 Oct;177(19):5704-6. doi: 10.1128/jb.177.19.5704-5706.1995.
2
Glucose transport by a mutant of Streptococcus mutans unable to accumulate sugars via the phosphoenolpyruvate phosphotransferase system.变形链球菌的一个突变体通过磷酸烯醇式丙酮酸磷酸转移酶系统无法积累糖类时的葡萄糖转运。
J Bacteriol. 1995 May;177(9):2251-8. doi: 10.1128/jb.177.9.2251-2258.1995.
3
Regulation of sugar uptake via the multiple sugar metabolism operon by the phosphoenolpyruvate-dependent sugar phosphotransferase transport system of Streptococcus mutans.变形链球菌磷酸烯醇式丙酮酸依赖性糖磷酸转移酶转运系统对多糖代谢操纵子介导的糖摄取的调控
Dev Biol Stand. 1995;85:351-6.
4
Global transcriptional analysis of Streptococcus mutans sugar transporters using microarrays.利用微阵列对变形链球菌糖转运蛋白进行全基因组转录分析。
J Bacteriol. 2007 Jul;189(14):5049-59. doi: 10.1128/JB.00338-07. Epub 2007 May 11.
5
Effect of growth conditions on levels of components of the phosphoenolpyruvate:sugar phosphotransferase system in Streptococcus mutans and Streptococcus sobrinus grown in continuous culture.生长条件对变形链球菌和远缘链球菌在连续培养中磷酸烯醇式丙酮酸：糖磷酸转移酶系统各组分水平的影响。
J Bacteriol. 1987 Dec;169(12):5686-91. doi: 10.1128/jb.169.12.5686-5691.1987.
6
Evidence for the involvement of proton motive force in the transport of glucose by a mutant of Streptococcus mutans strain DR0001 defective in glucose-phosphoenolpyruvate phosphotransferase activity.关于质子动力在变形链球菌DR0001菌株的葡萄糖 - 磷酸烯醇丙酮酸磷酸转移酶活性缺陷突变体转运葡萄糖过程中所起作用的证据。
Infect Immun. 1982 May;36(2):567-75. doi: 10.1128/iai.36.2.567-575.1982.
7
Regulation of ATP-dependent P-(Ser)-HPr formation in Streptococcus mutans and Streptococcus salivarius.变形链球菌和唾液链球菌中ATP依赖的P-(Ser)-HPr形成的调控
J Bacteriol. 1995 May;177(10):2751-9. doi: 10.1128/jb.177.10.2751-2759.1995.
8
Properties of Streptococcus mutans Ingbritt growing on limiting sucrose in a chemostat: repression of the phosphoenolpyruvate phosphotransferase transport system.变形链球菌英布里特株在恒化器中以限量蔗糖生长的特性：磷酸烯醇式丙酮酸磷酸转移酶转运系统的阻遏
Infect Immun. 1982 May;36(2):576-81. doi: 10.1128/iai.36.2.576-581.1982.
9
Concentration-dependent repression of the soluble and membrane components of the Streptococcus mutans phosphoenolpyruvate: sugar phosphotransferase system by glucose.葡萄糖对变形链球菌磷酸烯醇丙酮酸：糖磷酸转移酶系统的可溶性和膜成分的浓度依赖性抑制作用
J Bacteriol. 1989 Jun;171(6):2942-8. doi: 10.1128/jb.171.6.2942-2948.1989.
10
The multiple-sugar metabolism (msm) gene cluster of Streptococcus mutans is transcribed as a single operon.变形链球菌的多种糖代谢（msm）基因簇作为一个单一操纵子进行转录。
FEMS Microbiol Lett. 1996 Jul 1;140(2-3):261-4. doi: 10.1016/0378-1097(96)00191-7.

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Essential Roles of the Fructose-Phosphate Phosphohydrolase Operon in Carbohydrate Metabolism and Virulence Expression by .果糖-磷酸磷酸水解酶操纵子在碳水化合物代谢和 的毒力表达中的重要作用。
J Bacteriol. 2018 Dec 20;201(2). doi: 10.1128/JB.00586-18. Print 2019 Jan 15.
2
Sugar Allocation to Metabolic Pathways is Tightly Regulated and Affects the Virulence of Streptococcus mutans.糖类向代谢途径的分配受到严格调控，并影响变形链球菌的毒力。
Genes (Basel). 2016 Dec 28;8(1):11. doi: 10.3390/genes8010011.
3
Genes involved in the repression of mutacin I production in Streptococcus mutans.参与变形链球菌中变链菌素I产生抑制的基因。
Microbiology (Reading). 2009 Feb;155(Pt 2):551-556. doi: 10.1099/mic.0.021303-0.
4
Streptococcus mutans: fructose transport, xylitol resistance, and virulence.变形链球菌：果糖转运、木糖醇抗性与毒力。
J Dent Res. 2006 Apr;85(4):369-73. doi: 10.1177/154405910608500417.
5
Metabolism of fructooligosaccharides by Lactobacillus paracasei 1195.副干酪乳杆菌1195对低聚果糖的代谢
Appl Environ Microbiol. 2003 Apr;69(4):2217-22. doi: 10.1128/AEM.69.4.2217-2222.2003.
6
Analysis of Streptococcus mutans proteins modulated by culture under acidic conditions.变形链球菌在酸性条件下培养所调控蛋白质的分析
Appl Environ Microbiol. 2002 May;68(5):2382-90. doi: 10.1128/AEM.68.5.2382-2390.2002.
7
RegG, a CcpA homolog, participates in regulation of amylase-binding protein A gene (abpA) expression in Streptococcus gordonii.RegG是一种CcpA同源物，参与戈登氏链球菌中淀粉酶结合蛋白A基因（abpA）表达的调控。
J Bacteriol. 2001 Jun;183(11):3521-5. doi: 10.1128/JB.183.11.3521-3525.2001.
8
Regulation of the alpha-galactosidase activity in Streptococcus pneumoniae: characterization of the raffinose utilization system.肺炎链球菌中α-半乳糖苷酶活性的调控：棉子糖利用系统的特性
Genome Res. 1999 Dec;9(12):1189-97. doi: 10.1101/gr.9.12.1189.
9
Identification of a homolog of CcpA catabolite repressor protein in Streptococcus mutans.变形链球菌中碳分解代谢物阻遏蛋白CcpA同源物的鉴定。
Infect Immun. 1998 May;66(5):2085-92. doi: 10.1128/IAI.66.5.2085-2092.1998.
10
Listeria monocytogenes Scott A transports glucose by high-affinity and low-affinity glucose transport systems.单核细胞增生李斯特菌斯科特A通过高亲和力和低亲和力葡萄糖转运系统转运葡萄糖。
Appl Environ Microbiol. 1997 Feb;63(2):543-6. doi: 10.1128/aem.63.2.543-546.1997.

本文引用的文献

1
Regulation of glycerol metabolism in Enterococcus faecalis by phosphoenolpyruvate-dependent phosphorylation of glycerol kinase catalyzed by enzyme I and HPr of the phosphotransferase system.粪肠球菌中甘油代谢的调控，通过磷酸烯醇丙酮酸依赖的磷酸化作用，该磷酸化由磷酸转移酶系统的酶I和HPr催化甘油激酶来实现。
J Bacteriol. 1993 Jun;175(12):3730-3. doi: 10.1128/jb.175.12.3730-3733.1993.
2
The role of phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, in the regulation of carbon metabolism in gram-positive bacteria.磷酸烯醇式丙酮酸-糖磷酸转移酶系统的磷酸载体蛋白HPr的磷酸化在革兰氏阳性菌碳代谢调控中的作用。
J Cell Biochem. 1993 Jan;51(1):19-24. doi: 10.1002/jcb.240510105.
3
Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.细菌的磷酸烯醇丙酮酸：碳水化合物磷酸转移酶系统
Microbiol Rev. 1993 Sep;57(3):543-94. doi: 10.1128/mr.57.3.543-594.1993.
4
Positive selection for resistance to 2-deoxyglucose gives rise, in Streptococcus salivarius, to seven classes of pleiotropic mutants, including ptsH and ptsI missense mutants.对2-脱氧葡萄糖抗性的正向选择在唾液链球菌中产生了七类多效性突变体，包括ptsH和ptsI错义突变体。
Mol Microbiol. 1994 Sep;13(6):1101-9. doi: 10.1111/j.1365-2958.1994.tb00501.x.
5
Glucose transport by a mutant of Streptococcus mutans unable to accumulate sugars via the phosphoenolpyruvate phosphotransferase system.变形链球菌的一个突变体通过磷酸烯醇式丙酮酸磷酸转移酶系统无法积累糖类时的葡萄糖转运。
J Bacteriol. 1995 May;177(9):2251-8. doi: 10.1128/jb.177.9.2251-2258.1995.
6
Regulation of glycerol uptake by the phosphoenolpyruvate-sugar phosphotransferase system in Bacillus subtilis.枯草芽孢杆菌中磷酸烯醇式丙酮酸-糖磷酸转移酶系统对甘油摄取的调控
J Bacteriol. 1984 Jul;159(1):243-50. doi: 10.1128/jb.159.1.243-250.1984.
7
Role of Streptococcus mutans in human dental decay.变形链球菌在人类龋齿中的作用。
Microbiol Rev. 1986 Dec;50(4):353-80. doi: 10.1128/mr.50.4.353-380.1986.
8
Stimulation of dihydroxyacetone and glycerol kinase activity in Streptococcus faecalis by phosphoenolpyruvate-dependent phosphorylation catalyzed by enzyme I and HPr of the phosphotransferase system.磷酸烯醇丙酮酸依赖的磷酸化作用（由磷酸转移酶系统的酶I和HPr催化）对粪肠球菌中二羟基丙酮和甘油激酶活性的刺激作用。
J Bacteriol. 1986 Jun;166(3):829-36. doi: 10.1128/jb.166.3.829-836.1986.
9
Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial phosphoenolpyruvate: sugar phosphotransferase system.细菌磷酸烯醇丙酮酸：糖磷酸转移酶系统对诱导物排斥和分解代谢物阻遏的蛋白质磷酸化及变构调控
Microbiol Rev. 1989 Mar;53(1):109-20. doi: 10.1128/mr.53.1.109-120.1989.
10
Carbohydrate uptake in the oral pathogen Streptococcus mutans: mechanisms and regulation by protein phosphorylation.口腔病原菌变形链球菌中的碳水化合物摄取：蛋白质磷酸化的机制与调控
Biochimie. 1989 Sep-Oct;71(9-10):997-1004. doi: 10.1016/0300-9084(89)90103-x.

通过磷酸烯醇式丙酮酸磷酸转移酶系统对变形链球菌多种糖代谢操纵子介导的糖转运进行调控。

Regulation of sugar transport via the multiple sugar metabolism operon of Streptococcus mutans by the phosphoenolpyruvate phosphotransferase system.

作者信息

Cvitkovitch D G, Boyd D A, Hamilton I R

机构信息

Department of Oral Biology, Faculty of Dentistry, University of Manitoba, Winnipeg, Canada.

出版信息

J Bacteriol. 1995 Oct;177(19):5704-6. doi: 10.1128/jb.177.19.5704-5706.1995.

DOI:10.1128/jb.177.19.5704-5706.1995
PMID:7559362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177384/
Abstract

In this report, we provide evidence that the transport of sugars in Streptococcus mutans via the multiple sugar metabolism system is regulated by the phosphoenolpyruvate phosphotransferase system. A ptsI-defective mutant (DC10), when grown on the multiple sugar metabolism system substrate raffinose, exhibited reduced growth, transport, and glycolytic activity with raffinose relative to the parent strain BM71. Inhibition of [3H]raffinose uptake was also observed in both BM71 and DC10 with increasing concentrations of glucose and the glucose analogs alpha-methyl glucoside and 2-deoxyglucose.

摘要

在本报告中，我们提供了证据表明变形链球菌中糖类通过多种糖代谢系统的转运受磷酸烯醇式丙酮酸磷酸转移酶系统调控。一个ptsI缺陷突变体（DC10），当在多种糖代谢系统底物棉子糖上生长时，相对于亲本菌株BM71，其在棉子糖上的生长、转运和糖酵解活性降低。在BM71和DC10中，随着葡萄糖及葡萄糖类似物α-甲基葡萄糖苷和2-脱氧葡萄糖浓度的增加，也观察到了[3H]棉子糖摄取的抑制。