通过磷酸烯醇式丙酮酸磷酸转移酶系统对变形链球菌多种糖代谢操纵子介导的糖转运进行调控。
Regulation of sugar transport via the multiple sugar metabolism operon of Streptococcus mutans by the phosphoenolpyruvate phosphotransferase system.
作者信息
Cvitkovitch D G, Boyd D A, Hamilton I R
机构信息
Department of Oral Biology, Faculty of Dentistry, University of Manitoba, Winnipeg, Canada.
出版信息
J Bacteriol. 1995 Oct;177(19):5704-6. doi: 10.1128/jb.177.19.5704-5706.1995.
Abstract
In this report, we provide evidence that the transport of sugars in Streptococcus mutans via the multiple sugar metabolism system is regulated by the phosphoenolpyruvate phosphotransferase system. A ptsI-defective mutant (DC10), when grown on the multiple sugar metabolism system substrate raffinose, exhibited reduced growth, transport, and glycolytic activity with raffinose relative to the parent strain BM71. Inhibition of [3H]raffinose uptake was also observed in both BM71 and DC10 with increasing concentrations of glucose and the glucose analogs alpha-methyl glucoside and 2-deoxyglucose.
摘要
在本报告中，我们提供了证据表明变形链球菌中糖类通过多种糖代谢系统的转运受磷酸烯醇式丙酮酸磷酸转移酶系统调控。一个ptsI缺陷突变体（DC10），当在多种糖代谢系统底物棉子糖上生长时，相对于亲本菌株BM71，其在棉子糖上的生长、转运和糖酵解活性降低。在BM71和DC10中，随着葡萄糖及葡萄糖类似物α-甲基葡萄糖苷和2-脱氧葡萄糖浓度的增加，也观察到了[3H]棉子糖摄取的抑制。
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