Rauramo L, Punnonen R, Kaihola H L, Grönroos M
Maturitas. 1978 Sep;1(2):71-8. doi: 10.1016/0378-5122(78)90013-0.
Serum oestriol, oestrone and 17 beta-oestradiol concentrations during oral oestriol succinate treatment were investigated in ovariectomized women. Either a single dose of 8 mg or two doses of 4 mg were given daily. With the second divided dosage the serum oestriol levels remained uniform. The oestriol concentrations were clearly higher than in the beginning or in the middle of the normal menstrual cycle in the fertile woman. With both treatment schemes the ratio E3/(E2 + E1) was clearly higher than before treatment and during the normal menstrual cycle. Oestriol succinate treatment lowered the ratio E1/(E2 + E3), which was rather similar to the one during normal menstrual cycle.
对接受口服琥珀酸雌三醇治疗的卵巢切除女性的血清雌三醇、雌酮和17β-雌二醇浓度进行了研究。每日给予单次剂量8mg或两次剂量各4mg。采用第二次分剂量给药时，血清雌三醇水平保持稳定。雌三醇浓度明显高于有生育能力女性正常月经周期开始时或中期的浓度。两种治疗方案下，E3/(E2 + E1)的比值均明显高于治疗前及正常月经周期期间。琥珀酸雌三醇治疗降低了E1/(E2 + E3)的比值，该比值与正常月经周期期间的比值相当。
