Rauramo L, Punnonen R, Grönroos M
Maturitas. 1978 Sep;1(2):79-85. doi: 10.1016/0378-5122(78)90014-2.
Serum oestrone, oestradiol and oestriol concentrations were investigated during oral treatment with oestradiol valerate and oestriol succinate in ovariectomized women. The dosages used were 1 mg oestradiol valerate in the morning and 2 mg oestriol succinate in the evening of the first day and 2 mg oestradiol valerate in the morning of the second day of treatment. The other group of patients received the same therapy in reverse order. The variation in the serum oestrone and oestradiol concentrations with a daily dose of 1 or 2 mg of oestradiol valerate were considerable. 2 mg oestriol succinate caused a fairly small elevation of serum oestriol concentration. In both treatment groups the quotient E3/(E2 + E1) was similar to that found at the 6-7th day and in the middle of the normal menstrual cycle, the quotient E1/(E2 + E3) was somewhat higher than during normal cycle.
在对卵巢切除术后的女性进行戊酸雌二醇和琥珀酸雌三醇口服治疗期间，对血清雌酮、雌二醇和雌三醇浓度进行了研究。所用剂量为治疗第一天早晨1毫克戊酸雌二醇、晚上2毫克琥珀酸雌三醇，以及治疗第二天早晨2毫克戊酸雌二醇。另一组患者接受顺序相反的相同治疗。每日服用1或2毫克戊酸雌二醇时，血清雌酮和雌二醇浓度变化相当大。2毫克琥珀酸雌三醇使血清雌三醇浓度有相当小的升高。在两个治疗组中，E3/(E2 + E1)的比值与在正常月经周期第6 - 7天和周期中期时发现的比值相似，E1/(E2 + E3)的比值略高于正常周期。
