Mol J A, Henzen-Logmans S C, Hageman P, Misdorp W, Blankenstein M A, Rijnberk A
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
J Clin Endocrinol Metab. 1995 Oct;80(10):3094-6. doi: 10.1210/jcem.80.10.7559904.
Progestins cause a syndrome of growth hormone (GH) excess and enhanced mammary tumorigenesis in the dog. This has been regarded as being specific for the dog. Recently we reported that progestin-induced GH excess originates from foci of hyperplastic ductular epithelium of the mammary gland in the dog. In the present report we demonstrate by reverse-transcriptase PCR and immunohistochemistry that a main factor involved in tissue growth, i.e. GH, is also expressed in normal and neoplastic human mammary glands. The gene expressed in the human mammary gland proved to be identical to the gene encoding GH in the pituitary gland. The role of progesterone in the GH expression of the human mammary gland needs, however, to be proven. It is hypothesized that this locally produced hGH may play a pathogenetic role in breast cancer.
孕激素会在犬类中引发生长激素（GH）过量综合征，并增强乳腺肿瘤的发生。这一直被认为是犬类特有的现象。最近我们报道，孕激素诱导的GH过量源于犬类乳腺增生性导管上皮灶。在本报告中，我们通过逆转录聚合酶链反应和免疫组织化学证明，组织生长的一个主要因素即GH，也在正常和肿瘤性人类乳腺中表达。在人类乳腺中表达的基因被证明与垂体中编码GH的基因相同。然而，孕激素在人类乳腺GH表达中的作用尚需证实。据推测，这种局部产生的hGH可能在乳腺癌的发病机制中发挥作用。
