Widmer J, Henrotte J G, Raffin Y, Bovier P, Hilleret H, Gaillard J M
Service de la Recherche Biologique, Institutions Universitaires de Psychiatrie de Genève (IUPG), Switzerland.
J Affect Disord. 1995 Jun 8;34(3):201-9. doi: 10.1016/0165-0327(95)00018-i.
53 male and female drug-free major depressed patients were separated into three groups according to the severity of the depression. In the entire regrouped population, plasma and erythrocyte magnesium (Mg) were shown to increase as compared with 48 healthy controls, confirming our previous studies. The middle and highly depressed patients had higher erythrocyte and also plasma Mg levels than either lowly depressed patients or controls. Only, a few differences were noticed in plasma sodium, potassium and calcium (Ca) in the three groups of patients, except for ultrafiltrable plasma Ca, measured for the first time in affective disorders. Thus, erythrocyte and also plasma Mg are shown to be associated with the intensity of the depression. As blood hypomagnaesemia is often related to hyperexcitability, further investigations are actually in process to shown whether hypermagnesaemia might be, in contrast, associated with psychomotor retardation as observed in many depressed patients.
53名未服用药物的重度抑郁症男女患者根据抑郁严重程度分为三组。在整个重新分组的人群中，与48名健康对照者相比，血浆和红细胞镁（Mg）水平升高，证实了我们之前的研究。中度和重度抑郁患者的红细胞以及血浆镁水平高于轻度抑郁患者或对照者。在三组患者中，除了首次在情感障碍中测量的可超滤血浆钙外，血浆钠、钾和钙（Ca）仅发现了一些差异。因此，红细胞以及血浆镁与抑郁强度相关。由于血液低镁血症常与过度兴奋有关，目前正在进行进一步研究，以确定高镁血症是否可能与许多抑郁症患者中观察到的精神运动迟缓有关。
