Feigenbaum B A, Stevenson D D, Simon R A
Scripps Clinic and Research Foundation, La Jolla, CA 92037, USA.
J Allergy Clin Immunol. 1995 Oct;96(4):545-8. doi: 10.1016/s0091-6749(95)70299-7.
Bronchospasm after intravenous hydrocortisone treatment has been reported in some patients with aspirin-sensitive respiratory disease.
This study was designed to determine the prevalence of sensitivity to hydrocortisone among patients with aspirin-sensitive respiratory disease.
We performed double-blind, placebo-controlled challenges with aspirin and 100 mg of hydrocortisone sodium succinate administered intravenously in 53 subjects.
Forty-five of the 53 subjects (85%) undergoing oral aspirin challenge experienced respiratory reactions to aspirin. Forty-four of these 45 patients had neither naso-ocular, cutaneous, nor respiratory reactions to hydrocortisone sodium succinate. One aspirin-sensitive subject had bronchospasm and a naso-ocular reaction to hydrocortisone sodium succinate and a naso-ocular reaction with minimal bronchospasm to methylprednisolone sodium succinate. After desensitization to aspirin, and while receiving maintenance aspirin therapy, this subject again reacted to hydrocortisone sodium succinate with bronchospasm and naso-ocular reaction.
We conclude that aspirin-sensitive patients with asthma are not preferentially sensitive to hydrocortisone and that hydrocortisone sodium succinate does not cross-react or cross-desensitize with aspirin.
在一些对阿司匹林敏感的呼吸道疾病患者中，已报道静脉注射氢化可的松治疗后出现支气管痉挛。
本研究旨在确定对阿司匹林敏感的呼吸道疾病患者中氢化可的松敏感性的患病率。
我们对53名受试者进行了双盲、安慰剂对照试验，静脉注射阿司匹林和100mg琥珀酸钠氢化可的松。
53名接受口服阿司匹林激发试验的受试者中有45名（85%）对阿司匹林出现呼吸道反应。这45名患者中有44名对琥珀酸钠氢化可的松既无鼻眼、皮肤反应，也无呼吸道反应。一名对阿司匹林敏感的受试者对琥珀酸钠氢化可的松出现支气管痉挛和鼻眼反应，对琥珀酸钠甲泼尼龙出现鼻眼反应并伴有轻微支气管痉挛。在对阿司匹林脱敏后，且在接受维持性阿司匹林治疗期间，该受试者再次对琥珀酸钠氢化可的松出现支气管痉挛和鼻眼反应。
我们得出结论，阿司匹林敏感的哮喘患者对氢化可的松无优先敏感性，且琥珀酸钠氢化可的松与阿司匹林无交叉反应或交叉脱敏作用。
