Newton J, Round L, Curson R
Acta Eur Fertil. 1978 Sep;9(3):161-7.
212 consecutive pregnancies are reviewed in previously infertile women. 96 had conceived following treatment, 21 in a "rest cycle" after treatment, 60 during investigations and 35 before investigations were started. There were 25 miscarriages (11.8%), 13 following hormone treatment. There were 7 multiple pregnancies, 2 sets of triplets and 5 sets of twins. The multiple pregnancy rate with Clomiphene was 3.9% and with gonadotrophins 30%. Pregnancy after the first trimester was normal, 82 (44%) were induced, 79% laboured for less than 12 hours. Spontaneous vaginal delivery occurred in 107 patients (55%), forceps delivery in 34%, breach 5.6% and caesarean section 6.1%. Only 20 babies weighed less than 2500 grams (10.5%) and 168 (88%) had an apgar score greater than 5. These infertile patients were matched with a control group of our normal obstetric population. There was no significant difference between the control and infertile patients except for a higher induction rate (p less than 0.0005) and higher forceps rate (p less than 0.001) in the infertile patients. We conclude that pregnancy following infertility is associated with a higher spontaneous miscarriage rate, but otherwise is normal.
对既往不孕的女性的212例连续妊娠进行了回顾。96例在治疗后受孕，21例在治疗后的“休息周期”受孕，60例在检查期间受孕，35例在检查开始前受孕。有25例流产（11.8%），其中13例在激素治疗后。有7例多胎妊娠，2例三胞胎和5例双胞胎。克罗米芬治疗后的多胎妊娠率为3.9%，促性腺激素治疗后的多胎妊娠率为30%。孕中期后的妊娠情况正常，82例（44%）引产，79%的产妇分娩时间少于12小时。107例患者（55%）自然阴道分娩，34%产钳助产，5.6%臀位分娩，6.1%剖宫产。只有20例婴儿体重低于2500克（10.5%），168例（88%）阿氏评分大于5分。这些不孕患者与我们正常产科人群的对照组进行了匹配。除不孕患者的引产率较高（p<0.0005）和产钳助产率较高（p<0.001）外，对照组和不孕患者之间无显著差异。我们得出结论，不孕后的妊娠与较高的自然流产率相关，但其他方面是正常的。
