Safi F, Kuhns V, Beger H G
Department of General Surgery, University of Ulm, Germany.
Int J Biol Markers. 1995 Apr-Jun;10(2):100-6. doi: 10.1177/172460089501000206.
In order to assess the utility of the tumor-associated antigen CA 72-4 in the diagnosis and monitoring of gastric cancer, this tumor marker was measured preoperatively in 718 patients. This group comprised 282 patients with malignant disease (115 with gastric cancer and 167 with other malignancies not involving the stomach) and 476 patients with benign surgical diseases. These results were compared with those for carcinoembryonic antigen (CEA) and the tumor-associated antigen CA 19-9. CA 72-4 was above the normal limit of 2.5 U/ml in 61% of the patients with gastric cancer, in 35% of the patients with other malignancies, and in 7% of the patients with benign diseases. CEA and CA 19-9 were elevated in 37% of the patients with gastric cancer ( > 3 ng/ml for CEA and > 37 U/ml for CA 19-9). CA 72-4 levels were above 10 U/ml in 26% of the gastric cancer patients, in 15% of patients with other malignancies, and in 0.4% of the patients with benign diseases. There was a good correlation between CA 72-4 level and tumor stage in gastric cancer. CA 72-4 serum levels were over 2.5 U/ml in 31%, 48%, 68% and 88% of patients with stage I, II, III and IV disease, respectively. CA 72-4 was found to be more sensitive than CEA and CA 19-9 in detecting recurrences of gastric cancer. In the postoperative-care period, carcinoma recurred in 29 patients.(ABSTRACT TRUNCATED AT 250 WORDS)
为评估肿瘤相关抗原CA 72 - 4在胃癌诊断和监测中的效用，对718例患者术前测定了该肿瘤标志物。该组包括282例恶性疾病患者（115例胃癌患者和167例其他非胃部恶性肿瘤患者）以及476例良性外科疾病患者。将这些结果与癌胚抗原（CEA）和肿瘤相关抗原CA 19 - 9的结果进行比较。61%的胃癌患者、35%的其他恶性肿瘤患者以及7%的良性疾病患者的CA 72 - 4高于正常上限2.5 U/ml。37%的胃癌患者CEA（> 3 ng/ml）和CA 19 - 9（> 37 U/ml）升高。26%的胃癌患者、15%的其他恶性肿瘤患者以及0.4%的良性疾病患者的CA 72 - 4水平高于10 U/ml。胃癌中CA 72 - 4水平与肿瘤分期之间存在良好相关性。I、II、III和IV期疾病患者中，CA 72 - 4血清水平分别超过2.5 U/ml的比例为31%、48%、68%和88%。发现CA 72 - 4在检测胃癌复发方面比CEA和CA 19 - 9更敏感。在术后护理期间，29例患者出现癌症复发。（摘要截短至250字）
