表皮生长因子（EGF）、表皮生长因子受体（EGFR）和增殖细胞核抗原（PCNA）在喉部病变中的表达。

Expression of EGF, EGFR and PCNA in laryngeal lesions.

作者信息

Wen Q H, Nishimura T, Miwa T, Nagayama I, Furukawa M

机构信息

Department of Otolaryngology, School of Medicine, Kanazawa University, Japan.

出版信息

J Laryngol Otol. 1995 Jul;109(7):630-6. doi: 10.1017/s0022215100130889.

DOI:10.1017/s0022215100130889

PMID:7561470

Abstract

The expression of EGF/EGFR in 47 laryngeal surgical specimens from 44 patients was examined. PCNA analysis as an index of proliferating cells was also performed in 32 cases of laryngeal cancer, six cases of pre-cancerous lesions and nine cases of normal laryngeal mucosa. EGFR failed to show a significant correlation with tumour behaviour, but EGF expression was statistically significantly higher in malignant (SCC) than in non-malignant tissues (pre-cancerous and normal tissues) (p < 0.006), and PCNA also showed a statistically significant difference (p < 0.016) between the two. In malignant tissues when EGF/EGFR in 'double-positive' and 'double-negative' cases was compared, a statistically significant difference in PCNA was found (p < 0.029); but this was not seen in non-malignant tissues. Our results support the hypothesis that an autocrime mechanism exists in laryngeal cancer and in this mechanism EGF may play an important role in tumour progression, especially when EGFR is overexpressed.

摘要

对44例患者的47份喉手术标本中表皮生长因子（EGF）/表皮生长因子受体（EGFR）的表达进行了检测。还对32例喉癌、6例癌前病变和9例正常喉黏膜进行了增殖细胞核抗原（PCNA）分析（作为增殖细胞的指标）。EGFR与肿瘤行为未显示出显著相关性，但EGF在恶性（鳞状细胞癌）组织中的表达在统计学上显著高于非恶性组织（癌前组织和正常组织），（p < 0.006），PCNA在两者之间也有统计学显著差异（p < 0.016）。在恶性组织中比较 “双阳性” 和 “双阴性” 病例中的EGF/EGFR时，发现PCNA有统计学显著差异（p < 0.029）；但在非恶性组织中未观察到这种情况。我们的结果支持这样的假设，即喉癌中存在自分泌机制，在该机制中EGF可能在肿瘤进展中起重要作用，尤其是当EGFR过度表达时。