Kala S V, Jadhav A L
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston 77004, USA.
J Neurochem. 1995 Oct;65(4):1631-5. doi: 10.1046/j.1471-4159.1995.65041631.x.
The basal and K(+)-induced release of dopamine and its metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid, were measured in microdialysate samples obtained in vivo from the nucleus accumbens region of rat subchronically exposed to 50 ppm lead for 90 days. The basal and stimulus-induced release of dopamine and the metabolites were significantly reduced in the lead-exposed rats as compared with the controls. These reductions in dopamine and its metabolites are consistent with the reports of decreased dopamine availability associated with lead-induced changes in certain behavioral indices (fixed-interval performance) in rats. Furthermore, these changes were observed at blood lead levels similar to those considered to cause impairment in cognitive functions in children.
在对大鼠进行90天亚慢性50 ppm铅暴露后，从其伏隔核区域体内采集的微透析样本中，测定了多巴胺及其代谢产物3,4-二羟基苯乙酸和高香草酸的基础释放量以及钾离子诱导的释放量。与对照组相比，铅暴露大鼠体内多巴胺及其代谢产物的基础释放量和刺激诱导释放量均显著降低。多巴胺及其代谢产物的这些减少与大鼠体内铅诱导的某些行为指标（固定间隔表现）变化所导致的多巴胺可用性降低的报道一致。此外，在与被认为会导致儿童认知功能受损的血铅水平相似的情况下，观察到了这些变化。
