Lindholm P, Leskinen S, Någren K, Lehikoinen P, Ruotsalainen U, Teräs M, Joensuu H
Department of Oncology and Radiotherapy, Cyclotron/PET Center, University of Turku, Finland.
J Nucl Med. 1995 Oct;36(10):1806-10.
The purpose of the study was to assess the feasibility of PET and L-[methyl-11C]methionine (11C-methionine) in the detection of malignant melanoma.
Ten patients diagnosed with malignant melanoma (two with primary melanoma and eight with metastatic melanoma of the skin) but had no liver metastases underwent a PET study before starting cancer therapy. Dynamic scanning was performed for 40 min in seven patients and 10-20 min in three patients 25-45 min postinjection.
Carbon-11-methionine PET detected all melanoma lesions greater than 1.5 cm (n = 22) in diameter, whereas five smaller pulmonary lesions were not detected. The average standardized uptake value of the untreated lesions was 6.3 +/- 2.1 (n = 19) and the uptake rate (influx constant) was 0.085 +/- 0.041 min-1 (n = 16).
PET imaging with 11C-methionine is an effective method for visualizing melanoma. It may also be useful in measuring tumor metabolic activity in vivo.
本研究的目的是评估正电子发射断层扫描（PET）及L-[-甲基-11C]蛋氨酸（11C-蛋氨酸）用于检测恶性黑色素瘤的可行性。
10例诊断为恶性黑色素瘤的患者（2例原发性黑色素瘤，8例皮肤转移性黑色素瘤），但无肝转移，在开始癌症治疗前接受了PET检查。7例患者在注射后25 - 45分钟进行了40分钟的动态扫描，3例患者进行了10 - 20分钟的动态扫描。
11C-蛋氨酸PET检测出所有直径大于1.5厘米的黑色素瘤病灶（n = 22），而5个较小的肺部病灶未被检测到。未经治疗的病灶的平均标准化摄取值为6.3±2.1（n = 19），摄取率（流入常数）为0.085±0.041分钟-1（n = 16）。
11C-蛋氨酸PET成像对于黑色素瘤的可视化是一种有效的方法。它可能也有助于在体内测量肿瘤代谢活性。
