Gritters L S, Francis I R, Zasadny K R, Wahl R L
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.
J Nucl Med. 1993 Sep;34(9):1420-7.
To assess the feasibility and accuracy of positron emission tomography (PET) in the detection of metastatic malignant melanoma, the authors studied 12 patients approximately 1 hr following a 10-mCi injection of 2-[18F]-fluoro-2-deoxy-D-glucose (FDG). Scan findings were compared to physical examination, imaging and biopsy results. For intra-abdominal visceral and lymph node metastases, the sensitivity of FDG-PET was 100% (15/15). PET also identified three metastatic foci noted only retrospectively on CT, and two metastatic foci seen only on follow-up CT several months later. Eight additional intense foci of FDG uptake that were seen on PET have not yet been confirmed as tumors. In superficial lymph nodes, PET correctly identified seven of seven metastatic lesions (including three cases involving normal-sized lymph nodes) and correctly predicted the absence of tumor in six of six lymph node regions, for an overall accuracy of 100% (13/13). The sensitivity of the PET technique for detecting small pulmonary lesions was lower than CT but this could be due to respiratory motion or prior cancer treatment. This initial experience demonstrates the feasibility and clinical potential of FDG-PET for the detection of regional and systemically metastatic malignant melanoma, particularly in extra-pulmonary lesions.
为评估正电子发射断层扫描（PET）在检测转移性恶性黑色素瘤中的可行性和准确性，作者对12例患者在注射10毫居里的2-[18F]-氟-2-脱氧-D-葡萄糖（FDG）后约1小时进行了研究。将扫描结果与体格检查、影像学检查及活检结果进行比较。对于腹内内脏和淋巴结转移，FDG-PET的敏感性为100%（15/15）。PET还发现了3个仅在回顾CT时才发现的转移灶，以及2个仅在数月后的随访CT中才发现的转移灶。PET上发现的另外8个FDG摄取强烈的病灶尚未被证实为肿瘤。在浅表淋巴结中，PET正确识别出7个转移灶中的7个（包括3例累及正常大小淋巴结的病例），并正确预测6个淋巴结区域中有6个无肿瘤，总体准确率为100%（13/13）。PET检测小肺部病灶的敏感性低于CT，但这可能是由于呼吸运动或既往癌症治疗所致。这一初步经验证明了FDG-PET在检测局部和全身转移性恶性黑色素瘤，特别是肺外病变方面的可行性和临床潜力。
