Torizuka T, Tamaki N, Inokuma T, Magata Y, Sasayama S, Yonekura Y, Tanaka A, Yamaoka Y, Yamamoto K, Konishi J
Department of Nuclear Medicine, Kyoto University Faculty of Medicine, Japan.
J Nucl Med. 1995 Oct;36(10):1811-7.
The present study was designed to assess glucose metabolism in hepatocellular carcinoma (HCC) with PET and [18F]fluorodeoxyglucose (FDG) and to compare the results with the measured in vitro enzymatic activity of glucose metabolism and the histologic grading of HCC.
Dynamic FDG-PET scans were obtained in 17 preoperative patients with HCC. From the serial tissue and arterial radioactivities obtained by dynamic PET, FDG kinetic rate constants (K1 to k4) were obtained. The standardized uptake value (SUV) was also determined from the images acquired 48 to 60 min after FDG administration. These PET results were compared with hexokinase and glucose-6-phosphatase (G6Pase) activities and histologic grading of HCC in surgically resected tumor materials. According to histologic grading, the tumors were divided into low-grade and high-grade HCCs.
The k3 and SUV of high-grade HCCs were significantly higher than those of low-grade HCCs (p < 0.005, each). In addition, high correlations were observed between the hexokinase activities and these two parameters (r = 0.715 0.768, respectively). In some HCCs, relatively high G6Pase activities and k4 values modified tumor FDG uptake.
FDG PET is a valuable method for assessing glucose metabolism and histologic grading of HCC.
本研究旨在通过正电子发射断层扫描（PET）和[18F]氟脱氧葡萄糖（FDG）评估肝细胞癌（HCC）中的葡萄糖代谢，并将结果与体外测量的葡萄糖代谢酶活性及HCC的组织学分级进行比较。
对17例术前HCC患者进行动态FDG-PET扫描。从动态PET获得的系列组织和动脉放射性中，得出FDG动力学速率常数（K1至k4）。还从FDG给药后48至60分钟采集的图像中确定标准化摄取值（SUV）。将这些PET结果与手术切除肿瘤材料中HCC的己糖激酶和葡萄糖-6-磷酸酶（G6Pase）活性及组织学分级进行比较。根据组织学分级，将肿瘤分为低级别和高级别HCC。
高级别HCC的k3和SUV显著高于低级别HCC（均为p < 0.005）。此外，己糖激酶活性与这两个参数之间存在高度相关性（分别为r = 0.715和0.768）。在一些HCC中，相对较高的G6Pase活性和k4值改变了肿瘤的FDG摄取。
FDG PET是评估HCC葡萄糖代谢和组织学分级的有价值方法。
