Tata S, Flynn G L, Weiner N D
University of Michigan College of Pharmacy, Ann Arbor, MI 48109-1065, USA.
J Pharm Sci. 1995 Jun;84(6):688-91. doi: 10.1002/jps.2600840605.
We have previously established that the relative concentrations of propylene glycol and ethanol as a binary solvent system have a significant effect on the skin penetration of 2% solutions of minoxidil at 50 microL/cm2. The present work extends these studies and investigates the penetration of minoxidil from the different vehicle combinations as functions of application volume and occlusion. Decreasing the application volume has a variable effect which depends on vehicle composition. Penetration of minoxidil from 100% ethanol solutions decreased linearly with application volume. Generally, irrespective of the volume applied, the penetration of minoxidil increased with increasing ethanol fraction with a maximum penetration at 90% ethanol. Penetration from all the formulations was enhanced upon occluding the skin, with greatest increase evident in solutions with higher volatile fraction. Penetration of minoxidil in vivo showed trends similar to those seen in vitro.
我们之前已经确定，作为二元溶剂体系的丙二醇和乙醇的相对浓度，对50微升/平方厘米的2%米诺地尔溶液的皮肤渗透性有显著影响。目前的工作扩展了这些研究，并研究了米诺地尔从不同载体组合中的渗透情况，作为给药体积和封闭的函数。降低给药体积具有取决于载体组成的可变效应。米诺地尔从100%乙醇溶液中的渗透随给药体积呈线性下降。一般来说，无论给药体积如何，米诺地尔的渗透都随着乙醇比例的增加而增加，在90%乙醇时渗透最大。封闭皮肤后，所有制剂的渗透都增强了，在挥发性分数较高的溶液中增加最为明显。米诺地尔在体内的渗透显示出与体外观察到的趋势相似。
