Abu-Shakra M, Urowitz M B, Gladman D D, Gough J
University of Toronto, Lupus Clinic, Wellesley Hospital, Ontario, Canada.
J Rheumatol. 1995 Jul;22(7):1265-70.
To analyze the factors associated with mortality in patients with systemic lupus erythematosus (SLE), followed prospectively in a single center.
The study included 665 patients with SLE followed over a 20-year period according to a standard protocol. Clinical laboratory information has been entered into a database. Univariate analysis was carried out to identify prognostic factors of death. The Cox proportional hazard regression model was used to estimate risk ratio of death.
Renal damage, thrombocytopenia, lung involvement, systemic lupus erythematosus disease activity index (SLEDAI) > or = 20 at presentation, and age > or = 50 at diagnosis were predictive factors for mortality in the univariate as well as in the multivariate analyses. Hypertension and ischemic heart disease were significantly associated with death only in the univariate analysis.
Renal damage, thrombocytopenia, SLEDAI > or = 20 at presentation, lung involvement, and age > or = 50 at diagnosis are prognostic factors associated with mortality.
分析在单一中心前瞻性随访的系统性红斑狼疮（SLE）患者的死亡相关因素。
该研究纳入了665例SLE患者，按照标准方案进行了20年的随访。临床实验室信息已录入数据库。进行单因素分析以确定死亡的预后因素。采用Cox比例风险回归模型估计死亡风险比。
在单因素和多因素分析中，肾损害、血小板减少、肺部受累、就诊时系统性红斑狼疮疾病活动指数（SLEDAI）≥20以及诊断时年龄≥50岁均为死亡的预测因素。高血压和缺血性心脏病仅在单因素分析中与死亡显著相关。
肾损害、血小板减少、就诊时SLEDAI≥20、肺部受累以及诊断时年龄≥50岁是与死亡相关的预后因素。
