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身材矮小程度对垂体生长激素储备试验反应类型的影响

[Effect of the degree of short stature on the type of response to tests of pituitary growth hormone reserve].

作者信息

Bellastella A, Esposito V, D'Alessandro B, Piccolo C, Officioso N

出版信息

Boll Soc Ital Biol Sper. 1978 Dec 30;54(24):2565-9.

PMID:756278
Abstract

Two HGH (insulin and L-Dopa) stimulating tests were performed at time interval on 65 subjects with short stature (SDs between -2 and -4.5 according to Tanner) and on 18 control subjects, in order to study the influence of short stature degree on the HGH behaviour during the stimulating tests. The results obtained show that: 1. Statistically the short stature degree does not affect the response to HGH stimulating tests. 2. Two tests are necessary to avoid erroneous diagnosis of dwarfism caused by lack of HGH. 3. No response to HGH stimulating tests in subjects with normal stature may prove a discrepancy between the hormone measured radioimmunologically and its biological action.

摘要

对65名身材矮小的受试者(根据坦纳标准,标准差在-2至-4.5之间)和18名对照受试者在一定时间间隔内进行了两次生长激素(胰岛素和左旋多巴)刺激试验,以研究身材矮小程度对刺激试验期间生长激素行为的影响。获得的结果表明:1. 从统计学角度来看,身材矮小程度并不影响对生长激素刺激试验的反应。2. 需要进行两次试验以避免因生长激素缺乏导致的侏儒症误诊。3. 身材正常的受试者对生长激素刺激试验无反应可能证明放射免疫测定的激素与其生物学作用之间存在差异。

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