抗高血压药物中毒：α-肾上腺素能受体拮抗剂。
Poisoning with anti-hypertensive drugs: alpha-adrenoceptor antagonists.
作者信息
Lip G Y, Ferner R E
机构信息
West Midlands Centre for Adverse Drug Reaction Reporting, City Hospital, Birmingham, UK.
出版信息
J Hum Hypertens. 1995 Jul;9(7):523-6.
PMID:7562879
Abstract
Experience with overdosage and toxicity with the alpha (alpha)-adrenoceptor antagonists remains very limited, and all the cases in the literature relate to prazosin overdosage. The selective alpha-blocker appears, however, to have a low acute toxicity. Supportive therapy by the reduction of gastrointestinal absorption, monitoring of vital signs and the correction of hypotension (with intravenous fluids) is indicated.
摘要
α-肾上腺素能受体拮抗剂的过量用药及毒性方面的经验仍然非常有限，且文献中所有病例均与哌唑嗪过量用药有关。然而，这种选择性α阻滞剂似乎急性毒性较低。建议采取通过减少胃肠道吸收、监测生命体征以及（通过静脉输液）纠正低血压等支持性治疗措施。
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