Ferrara N, Furgi G, Longobardi G, Nicolino A, Acanfora D, Leosco D, Rengo F
Clinica del Lavoro Foundation, Institute of Care and Research, Campoli del Monte Taburno (BN), Italy.
J Hum Hypertens. 1995 Jul;9(7):581-7.
To evaluate the effect of age on left ventricular hypertrophy-related arrhythmias in patients with essential arterial hypertension, 68 hypertensives (47 men and 21 women, mean age 59.4 +/- 9.5 years) without other cardiovascular disorders were studied. All patients underwent M-mode and two-dimensional echocardiogram and 24 h ambulatory electrocardiographic monitoring to measure left ventricular internal dimension, septum and posterior wall thickness, left ventricular mass index, premature ventricular beats and modified Lown grade. Premature ventricular beats (PVB) and modified Lown grade were significantly related to left ventricular mass index, but not to left ventricular internal dimension, fractional shortening, systolic and diastolic blood pressure. There was no relation between age and number of PVB, or severity of arrhythmias. In conclusion, in hypertensive patients only left ventricular hypertrophy, and not age, plays a significant role in the pathophysiology of the increased incidence of ventricular arrhythmias by a different mechanism than age-related increased ventricular arrhythmias.
为评估年龄对原发性高血压患者左心室肥厚相关心律失常的影响，我们对68例无其他心血管疾病的高血压患者（47例男性和21例女性，平均年龄59.4±9.5岁）进行了研究。所有患者均接受了M型和二维超声心动图检查以及24小时动态心电图监测，以测量左心室内径、室间隔和后壁厚度、左心室质量指数、室性早搏及改良的洛恩分级。室性早搏（PVB）和改良的洛恩分级与左心室质量指数显著相关，但与左心室内径、缩短分数、收缩压和舒张压无关。年龄与PVB数量或心律失常严重程度之间无关联。总之，在高血压患者中，只有左心室肥厚而非年龄，在室性心律失常发生率增加的病理生理过程中起重要作用，其机制与年龄相关的室性心律失常增加不同。
