家族性银屑病中基因异质性的证实。
Confirmation of genetic heterogeneity in familial psoriasis.
作者信息
Matthews D, Fry L, Powles A, Weissenbach J, Williamson R
机构信息
Department of Biochemistry and Molecular Genetics, St. Mary's/Imperial College, London, UK.
出版信息
J Med Genet. 1995 Jul;32(7):546-8. doi: 10.1136/jmg.32.7.546.
Psoriasis affects approximately 2% of the European population and is often familial. Linkage of a subset of psoriasis families to loci on chromosome 17q has recently been reported. We have studied members of a large multiply affected family from the north east of England and analysed genotypes for markers from 17q, including the polymorphic microsatellite markers AFM210xa5, AFM163yg1, AFM044xg3, AFMa353yg1, and AFM217yd19. Two point and multipoint analysis clearly show exclusion of linkage between the telomeric region of 17q and psoriasis in this family. This confirms the genetic heterogeneity of psoriasis and the existence of at least one other major psoriasis locus.
银屑病影响约2%的欧洲人口，且常具有家族性。最近有报道称，一部分银屑病家族与17号染色体长臂上的基因座存在连锁关系。我们研究了来自英格兰东北部一个多成员患病的大家族的成员，并分析了17号染色体长臂上标记物的基因型，包括多态性微卫星标记物AFM210xa5、AFM163yg1、AFM044xg3、AFMa353yg1和AFM217yd19。两点分析和多点分析清楚地表明，在这个家族中，17号染色体长臂的端粒区域与银屑病之间不存在连锁关系。这证实了银屑病的遗传异质性以及至少存在一个其他主要的银屑病基因座。
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