Wong H Y, Riedl C R, Griffith D P
Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA.
J Urol. 1995 Nov;154(5):1944-7.
To determine the effect of iontophoresis (electrical current for therapeutic purposes) on the growth of pathogenic bacteria in human urine.
Pathogenic bacteria were isolated and inoculated into a dynamic in vitro artificial bladder model. Pooled sterile human urine was regulated through the artificial bladder by intravenous tubing and pumps to simulate filling and emptying of the human bladder. The effect of electrical current on bacterial growth in the system was then studied.
When iontophoresis is applied at low bacterial concentrations ( < 10(8) colony forming units [CFU]/l.), inhibition of bacterial growth occurs. However, when iontophoresis is applied after fulminant growth of bacteria ( > 10(8) CFU/l.), no inhibition of bacterial growth occurs. Iontophoresis was not found to enhance the antibacterial action of gentamicin to resistant Pseudomonas aeruginosa.
Iontophoresis inhibits bacterial growth at low bacterial concentrations. It does not inhibit bacterial growth after infectious levels have been attained, and it does not potentiate the action of gentamicin on resistant Pseudomonas aeruginosa.
确定离子导入法（用于治疗目的的电流）对人尿液中病原菌生长的影响。
分离病原菌并接种到动态体外人工膀胱模型中。通过静脉输液管和泵将汇集的无菌人尿液调节通过人工膀胱，以模拟人膀胱的充盈和排空。然后研究电流对系统中细菌生长的影响。
当在低细菌浓度（<10⁸ 菌落形成单位[CFU]/升）下进行离子导入时，细菌生长受到抑制。然而，当在细菌暴发性生长后（>10⁸ CFU/升）进行离子导入时，未观察到细菌生长受到抑制。未发现离子导入增强庆大霉素对耐药铜绿假单胞菌的抗菌作用。
离子导入在低细菌浓度下抑制细菌生长。在达到感染水平后，它不会抑制细菌生长，并且不会增强庆大霉素对耐药铜绿假单胞菌的作用。
