Kanetake H, Igawa T, Kanda S, Saito Y
Department of Urology, Nagasaki University School of Medicine.
Nihon Rinsho. 1995 Aug;53(8):1894-9.
Renal tubular cells do not proliferate under normal intact conditions, whereas a marked regeneration is evident when tubular cells are injured by renal toxins or by ischemia. In case of compensatory renal growth too, hyperplasia of renal proximal tubular cells is observed. Various growth factors, including epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) seem to be involved in renal regeneration, however, the physiological role of these growth factors for the natural course of the renal regeneration have yet to be established. Hepatocyte growth factor (HGF), a potent mitogen for cultured renal tubular cells, may function as a renotropic factor, which enhances regeneration of the kidney. Once renal tubular cells are damaged by some agents, HGF mRNA, HGF activity and DNA synthesis of renal tubular cells are sequentially increased. Since both HGF mRMA and HGF protein are localized in renal interstitial cells, HGF seems to act on the tubular cells as a paracrine mediator. In addition to these results, HGF has multiple biological functions. This suggests that HGF possesses biological activities essential for renal regeneration.
在正常完整的情况下，肾小管细胞不会增殖，而当肾小管细胞受到肾毒素或缺血损伤时，明显的再生现象就会出现。在肾脏代偿性生长的情况下，也会观察到肾近端小管细胞的增生。包括表皮生长因子（EGF）和胰岛素样生长因子-I（IGF-I）在内的多种生长因子似乎参与了肾脏再生，然而，这些生长因子在肾脏再生自然过程中的生理作用尚未确定。肝细胞生长因子（HGF）是培养的肾小管细胞的一种强效促有丝分裂原，可能作为一种促肾因子发挥作用，促进肾脏再生。一旦肾小管细胞受到某些因素的损伤，HGF mRNA、HGF活性和肾小管细胞的DNA合成会依次增加。由于HGF mRMA和HGF蛋白都定位于肾间质细胞，HGF似乎作为旁分泌介质作用于肾小管细胞。除了这些结果外，HGF还具有多种生物学功能。这表明HGF拥有肾脏再生所必需的生物学活性。
