Sobel A T, Moisy M, Belghiti D, Gabay Y, Lagrue G
J Clin Lab Immunol. 1978 Nov;1(3):179-81.
Measurements of C2 hemolytic activity were performed in the sera of 13 patients with Hereditary Angioneurotic Edema. Prior to treatment, C2 values correlated with the severity of the disease in each patient. During androgen therapy with Danazol, C2 measurements reflected the clinical benefit of the drug more accurately than C4 levels, thus explaining the effectiveness of low drug doses. This study also suggests that breakdown products of C2 may play an essential role in the pathogenesis of the edema.
对13例遗传性血管性水肿患者的血清进行了C2溶血活性测定。治疗前，C2值与每位患者的疾病严重程度相关。在用达那唑进行雄激素治疗期间，C2测量比C4水平更准确地反映了药物的临床疗效，从而解释了低剂量药物的有效性。这项研究还表明，C2的分解产物可能在水肿的发病机制中起重要作用。
