Rowley H, O'Dwyer T P, Jones A S, Timon C I
Department of Otolaryngology, Royal Victoria Eye and Ear Hospital, Dublin.
Laryngoscope. 1995 Oct;105(10):1118-21. doi: 10.1288/00005537-199510000-00019.
While globus pharyngeus is a common disorder, accounting for 3% to 4% of new otolaryngology outpatient referrals, few long-term follow-up studies have been conducted on patients with this condition. The authors of this study followed 74 patients with a diagnosis of globus pharyngeus for an average of 7 years, 7 months (range: 7 years to 8 years, 10 months). During the follow-up period, 55% of patients were asymptomatic and 45% of patients had persistent symptoms. An in-depth analysis of features at clinical presentation failed to reveal any reliable prognostic indicators. A number of patients developed other conditions during the follow-up period, but no patient developed upper aerodigestive tract malignancy. This study represents the longest follow-up of globus patients to date and, to the authors' knowledge, is the first to address the issue of malignancy in globus.
虽然咽异感症是一种常见疾病，占耳鼻喉科新门诊转诊患者的3%至4%，但针对患有这种疾病的患者进行的长期随访研究却很少。本研究的作者对74例诊断为咽异感症的患者进行了平均7年零7个月（范围：7年至8年零10个月）的随访。在随访期间，55%的患者无症状，45%的患者有持续症状。对临床表现特征的深入分析未能揭示任何可靠的预后指标。一些患者在随访期间出现了其他病症，但没有患者发生上呼吸道消化道恶性肿瘤。这项研究是迄今为止对咽异感症患者最长时间的随访，据作者所知，也是首个探讨咽异感症患者恶性肿瘤问题的研究。
