支气管扩张剂对肾上腺髓质素和肾上腺髓质素原N端20肽反应的比较。

Comparison of bronchodilator responses to adrenomedullin and proadrenomedullin N-terminal 20 peptide.

作者信息

Kanazawa H, Kawaguchi T, Fujii T, Kudoh S, Hirata K, Kurihara N, Takeda T

机构信息

First Department of Internal Medicine, Osaka City University Medical School, Japan.

出版信息

Life Sci. 1995;57(16):PL241-5. doi: 10.1016/0024-3205(95)02117-2.

DOI:10.1016/0024-3205(95)02117-2

PMID:7564889

Abstract

This study was designed to determine and compare airway responses to synthetic human adrenomedullin(AM) and proadrenomedullin N-terminal 20 peptide (PAMP) in anesthetized guinea pigs in vivo. 10(-7) M AM and PAMP significantly inhibited acetylcholine-and histamine-induced bronchoconstriction. However, this significant bronchodilator effect of PAMP lasted about five minutes, which was much shorter than that of AM. In addition, the bronchodilator effect of AM is approximately 100-fold more potent than PAMP. We demonstrated that PAMP had a potent bronchodilator activity, and induced a rapid and short-lasting bronchodilation. These findings suggest that AM and PAMP may play important roles in airway functions.

摘要

本研究旨在测定并比较在体麻醉豚鼠对合成人肾上腺髓质素（AM）和肾上腺髓质素原N端20肽（PAMP）的气道反应。10⁻⁷M的AM和PAMP可显著抑制乙酰胆碱和组胺诱导的支气管收缩。然而，PAMP的这种显著支气管舒张作用持续约5分钟，比AM的作用持续时间短得多。此外，AM的支气管舒张作用比PAMP强约100倍。我们证明PAMP具有强大的支气管舒张活性，并可诱导快速且短暂的支气管舒张。这些发现提示AM和PAMP可能在气道功能中发挥重要作用。