Suzuki T, Tsuji M, Mori T, Misawa M, Nagase H
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Life Sci. 1995;57(17):PL247-52. doi: 10.1016/0024-3205(95)02139-a.
The effect of pretreatment with a delta opioid receptor antagonist, naltrindole (NTI), on the development of physical dependence on morphine was investigated in mice. Several withdrawal signs, an increase in cortical noradrenaline (NA) turnover and a decrease in dopamine (DA) turnover in the limbic forebrain were observed following naloxone challenge in morphine-dependent mice. Pretreatment with NTI (0.3-5 mg/kg, s.c.) during chronic morphine treatment dose-dependently suppressed the behavioral and biochemical changes after withdrawal. The blocking effects of NTI suggest that delta opioid receptors may play a significant role in modulating the development of physical dependence on morphine.
在小鼠中研究了用δ阿片受体拮抗剂纳曲吲哚（NTI）预处理对吗啡身体依赖性发展的影响。在吗啡依赖小鼠中进行纳洛酮激发后，观察到几种戒断症状、皮质去甲肾上腺素（NA）周转率增加以及边缘前脑多巴胺（DA）周转率降低。在慢性吗啡治疗期间用NTI（0.3 - 5毫克/千克，皮下注射）预处理剂量依赖性地抑制了戒断后的行为和生化变化。NTI的阻断作用表明δ阿片受体可能在调节吗啡身体依赖性的发展中起重要作用。
