De Paz J A, Villa J G, Vilades E, Martin-Nuño M A, Lasierra J, Gonzalez-Gallego J
Service of Hematology, San Millán Hospital, Logroño, Spain.
Med Sci Sports Exerc. 1995 Jul;27(7):961-6. doi: 10.1249/00005768-199507000-00003.
In this study the influence of low-dose oral contraceptives (OC) on the different components of the fibrinolytic system before and immediately after maximal exercise was examined in a group of 18 moderately active women. Nine women using OC and nine control women performed a maximal effort treadmill protocol. Comparison of the resting parameters revealed higher plasma FbDP, plasminogen, alpha 2-antiplasmin and protein C concentrations, and lower PAI activity in the OC group. No differences were observed in plasma concentrations of t-PA antigen, t-PA activity, PAI antigen, antithrombin III, and protein S. Acute maximal exercise resulted in significant increases in t-PA antigen, t-PA activity, t-PA/PAI complexes, and FbDP in both groups of subjects, while PAI activity was reduced. No significant differences were found for the change in those parameters between control and OC users. Exercise induced no variation in any of the groups for PAI antigen, alpha 2-antiplasmin, plasminogen, protein C, or protein S. Our data suggest that changes in the fibrinolytic system induced by physical exercise are not affected by oral contraceptives.
在本研究中，对18名中度活跃的女性进行了检测，以考察低剂量口服避孕药（OC）对最大运动前及运动后即刻纤溶系统不同组分的影响。9名服用OC的女性和9名对照女性进行了最大强度的跑步机运动方案。静息参数比较显示，OC组的血浆纤维蛋白降解产物（FbDP）、纤溶酶原、α2 -抗纤溶酶和蛋白C浓度较高，而纤溶酶原激活物抑制剂（PAI）活性较低。组织型纤溶酶原激活物（t - PA）抗原、t - PA活性、PAI抗原、抗凝血酶III和蛋白S的血浆浓度未观察到差异。急性最大运动导致两组受试者的t - PA抗原、t - PA活性、t - PA/PAI复合物和FbDP显著增加，而PAI活性降低。对照者和服用OC者之间这些参数的变化未发现显著差异。运动在任何组中均未引起PAI抗原、α2 -抗纤溶酶、纤溶酶原、蛋白C或蛋白S的变化。我们的数据表明，体育锻炼引起的纤溶系统变化不受口服避孕药的影响。
