Leong K W, Teh A, Bosco J J, Jayaranee S, Sadat U
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Med J Malaysia. 1995 Jun;50(2):158-61.
Antilymphocyte globulin (ALG) was given every other day for 5 doses with platelet transfusions immediately following ALG administration in 6 patients with aplastic anaemia. Four patients responded and 3 durable remissions were achieved. One patient relapsed and further treatment with anti-thymocyte globulin and cyclosporin also failed. One patient died of Flavobacterium septicaemia 6 days after completion of ALG. Our data suggests that using an alternate day regimen, a response rate similar to a daily regimen can be obtained.
对6例再生障碍性贫血患者每隔一天给予抗淋巴细胞球蛋白（ALG），共5剂，并在给予ALG后立即输注血小板。4例患者有反应，3例获得持久缓解。1例患者复发，使用抗胸腺细胞球蛋白和环孢素进一步治疗也失败。1例患者在完成ALG治疗6天后死于弗氏杆菌败血症。我们的数据表明，采用隔日给药方案可获得与每日给药方案相似的反应率。
