Ohbayashi Y, Nagai M, Sasaki K, Murata M, Tasaka T, Kubota Y, Ikeda K, Takahara J, Irino S
First Department of Internal Medicine, Kagawa Medical School.
Rinsho Ketsueki. 1993 May;34(5):673-5.
A 57-year-old female, who had a 14-year history of rheumatoid arthritis, developed aplastic anemia. Treatment with anti-lymphocyte globulin (ALG) and methylprednisolone pulse therapy achieved complete remission. However, twenty months after ALG treatment she developed acute monocytic leukemia. In spite of the chemotherapy, consisting of cytosine arabinoside and etoposide, she died of pneumonia. Recently, reports from Western countries have claimed that patients with aplastic anemia frequently develop clonal disorders following ALG treatment. To our knowledge, this is the first report in Japan of a case developing acute leukemia following ALG treatment.
一名57岁女性，有14年类风湿关节炎病史，发展为再生障碍性贫血。使用抗淋巴细胞球蛋白（ALG）和甲基强的松龙冲击疗法治疗后实现完全缓解。然而，在ALG治疗20个月后，她患上了急性单核细胞白血病。尽管采用了由阿糖胞苷和依托泊苷组成的化疗方案，她仍死于肺炎。最近，西方国家的报告称，再生障碍性贫血患者在接受ALG治疗后经常会出现克隆性疾病。据我们所知，这是日本首例关于ALG治疗后发生急性白血病的报告。
