Schmaltz C, Sauter S, Opitz O, Harms D, Kremens B, Lohner M, Metz K, Brandis M, Niemeyer C
University Children's Hospital, Freiburg, Germany.
Med Pediatr Oncol. 1995 Dec;25(6):479-84. doi: 10.1002/mpo.2950250612.
Pleuro-pulmonary blastoma is a rare malignant lung tumor in children and distinct from ordinary pulmonary blastoma of adulthood. Combination chemotherapy plays an important role in the treatment of this tumor, but so far no attempt of high dose chemotherapy with subsequent bone marrow or blood stem cell transplantation has been published. The case is reported of a 2-year-old boy with pleuro-pulmonary blastoma who achieved partial remission with conventional chemotherapy and surgery. Subsequent administration of high dose melphalan, etoposide, and carboplatin, followed by autologous blood stem cell transplantation resulted in a 3-month disease-free interval but did not prevent eventual local recurrence, leading to death within a few weeks. Clinical presentation, pathology, management, and prognosis are discussed and the literature reviewed.
肺胚细胞瘤是儿童罕见的恶性肺肿瘤，与成人的普通肺胚细胞瘤不同。联合化疗在该肿瘤的治疗中发挥着重要作用，但迄今为止，尚未见关于高剂量化疗后继以骨髓或血液干细胞移植的尝试的报道。本文报告了1例2岁患肺胚细胞瘤的男孩，该患儿通过传统化疗和手术获得了部分缓解。随后给予高剂量美法仑、依托泊苷和卡铂，继以自体血液干细胞移植，实现了3个月的无病间期，但未能防止最终的局部复发，导致患儿在数周内死亡。本文讨论了临床表现、病理、治疗及预后，并对相关文献进行了综述。
