Bongo S, Coze C, Scheiner C, Coquet M, Devred P, Bernard J L
Fédération d'oncologie pédiatrique du CHR de Marseille, hôpital de La Timone, Marseille, France.
Bull Cancer. 1996 Oct;83(10):877-81.
Pulmonary blastoma is a rare malignant tumor. A new case is reported in a 3 years 6 month-old girl. An apparent clinical remission was first obtained after a surgical treatment followed by a conventional chemotherapy during six months. Afterwards the persistence of a microscopic residual pulmonary disease lead us to deliver successfully an intensive chemotherapy followed by autologous peripheral blood stem cells reinjection. The child remains disease free 12 months after graft. Problems set by the histogenesis of this tumor, its unspecific clinical and paraclinical features and the role of conventional and intensive chemotherapy followed by autologous bone marrow transplantation are discussed on the basis of a review of 50 cases in the literature.
肺母细胞瘤是一种罕见的恶性肿瘤。本文报道了一名3岁6个月大女孩的新病例。手术治疗后进行了6个月的常规化疗，首次实现了明显的临床缓解。之后，显微镜下残留的肺部疾病持续存在，促使我们成功实施了强化化疗，随后进行自体外周血干细胞回输。移植后12个月，该患儿仍无疾病迹象。基于对文献中50例病例的回顾，讨论了该肿瘤的组织发生、非特异性临床和辅助检查特征以及常规和强化化疗后自体骨髓移植的作用所引发的问题。
