Schmid H P, Pouch M N, Petit F, Dadet M H, Badaoui S, Boissonnet G, Buri J, Norris V, Briand Y
Université Blaise Pascal, Clermont-Ferrand II, Aubière, France.
Mol Biol Rep. 1995;21(1):43-7. doi: 10.1007/BF00990969.
The 20S proteasome (prosome) is a highly organized multi-protein complex with approximate molecular weight of about 700 kDa. Whilst the role of the proteasome in the processing and turnover of cellular proteins is becoming clearer, its relationship with RNA remains obscure. Over the last decade the possibility of association of proteasomes with specific RNAs or mRNPs have been particularly controversial. Proteasomes were reported to inhibit translation of viral mRNAs and to be tightly associated with RNase activity. It is possible that proteasomes are also involved in cellular RNA breakdown and RNA processing like prokaryotic RNase E.
20S蛋白酶体（蛋白酶小体）是一种高度有序的多蛋白复合物，分子量约为700 kDa。虽然蛋白酶体在细胞蛋白质加工和周转中的作用越来越清晰，但其与RNA的关系仍不清楚。在过去十年中，蛋白酶体与特定RNA或mRNA-蛋白质复合物结合的可能性一直存在特别大的争议。据报道，蛋白酶体可抑制病毒mRNA的翻译，并与核糖核酸酶活性紧密相关。蛋白酶体也有可能像原核核糖核酸酶E一样参与细胞RNA的降解和加工。
