Mark M H, Sage J I, Walters A S, Duvoisin R C, Miller D C
Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903, USA.
Mov Disord. 1995 Jul;10(4):450-4. doi: 10.1002/mds.870100408.
We report three cases of autopsy-proven Binswanger's disease (subcortical arteriosclerotic encephalopathy) with unusual clinical features. Two patients had supranuclear gaze disturbances, early gait dysfunction, and speech disorders suggestive of progressive supranuclear palsy. One of these patients was not demented at the time of death. The third patient had features typical of Parkinson's disease. All three patients were responsive to treatment with levodopa. The clinical spectrum of Binswanger's disease should be expanded to include levodopa-responsive parkinsonism.
我们报告了三例经尸检证实的宾斯旺格病（皮质下动脉硬化性脑病），其具有不寻常的临床特征。两名患者有核上性凝视障碍、早期步态功能障碍以及提示进行性核上性麻痹的言语障碍。其中一名患者在死亡时未出现痴呆。第三名患者具有帕金森病的典型特征。所有三名患者对左旋多巴治疗均有反应。宾斯旺格病的临床谱应扩大到包括左旋多巴反应性帕金森综合征。
