Armstrong D D
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
Neuropediatrics. 1995 Apr;26(2):100-4. doi: 10.1055/s-2007-979736.
The syndrome which Andreas Rett and Bengt Hagberg first brought to our attention has been observed for eighteen years. It appears to be unlike any other disease of childhood. The original descriptions of Rett syndrome, as being autistic, degenerative and progressive are now, based on longitudinal observations, being questioned. In this paper the morphologic changes in the nervous system in Rett syndrome are summarized. The evidence against a degenerative process are presented, and the alternations are considered, along with the clinical features in terms of a possible arrest of brain development.
安德烈亚斯·雷特（Andreas Rett）和本特·哈格贝里（Bengt Hagberg）首次引起我们注意的这种综合征已经被观察了18年。它似乎与儿童期的任何其他疾病都不同。雷特综合征最初被描述为自闭症、退行性和进行性的，但基于纵向观察，现在这些描述正受到质疑。本文总结了雷特综合征神经系统的形态学变化。提出了反对退行性过程的证据，并结合可能的脑发育停滞的临床特征来考虑这些变化。
