Culić M, Saponjić J, Todorović V, Janković B, Udović S, Peković S, Stojiljković M, Ratković M, Nikolić A, Rakić L
Institute for Biological Research, Belgrade, Yugoslavia.
Neuropeptides. 1995 Jul;29(1):59-62. doi: 10.1016/0143-4179(95)90057-8.
The physiological and pathophysiological roles of neuropeptides are still not clear. The aim of our study was to detect long lasting changes of vasoactive-intestinal peptide (VIP), somatostatin (SOM) and substance P (SP) contents in the rat cerebral cortex and hippocampus after brain lesion. The experiments were performed on groups of adult male Wistar rats. The first group consisted of animals with unilateral ablation of the sensorimotor cortex performed at the age of 60 days. The second group was a control one (rats of the same age but with an intact brain). Both groups of animals were sacrificed at the age of 90-105 days and radioimmunoassay was used to determine amounts of VIP, SOM and SP. The mean values of VIP levels were decreased significantly only in contralateral cortical areas, while there was an increase of SP in lesioned animals. Our results suggest that descrete changes in neuropeptide levels occur during restorative processes after brain lesion.
神经肽的生理和病理生理作用仍不明确。我们研究的目的是检测脑损伤后大鼠大脑皮质和海马中血管活性肠肽（VIP）、生长抑素（SOM）和P物质（SP）含量的长期变化。实验在成年雄性Wistar大鼠组上进行。第一组由60日龄时进行单侧感觉运动皮质切除的动物组成。第二组为对照组（同龄但大脑完整的大鼠）。两组动物均在90 - 105日龄时处死，采用放射免疫分析法测定VIP、SOM和SP的含量。仅在对侧皮质区域VIP水平的平均值显著降低，而损伤动物中SP含量增加。我们的结果表明，脑损伤后的修复过程中神经肽水平会发生离散变化。
