Volz H P, Müller H, Möller H J
Psychiatric Department, Bonn University, Germany.
Neuropsychobiology. 1995;32(1):23-30. doi: 10.1159/000119208.
There is a rather limited database of controlled clinical trials on the comparative effects of antidepressants in elderly and non-elderly depressed patients. A common finding is reduced efficacy and an increased incidence of side effects. To further examine the question of efficacy and safety of antidepressant drugs in elderly versus non-elderly patients, the differential effects of a new selective type A monoamine oxidase inhibitor brofaromine, and the classical tricyclic imipramine were investigated using the data of two recently published trials. We found no major difference between non-elderly and elderly depressed patients as concerns efficacy, total incidence of adverse findings or safety parameters such as laboratory values and heart rate. These results are discussed in the light of some methodological questions and previous reports.
关于抗抑郁药对老年和非老年抑郁症患者的比较效果，对照临床试验的数据库相当有限。一个常见的发现是疗效降低和副作用发生率增加。为了进一步研究抗抑郁药在老年患者与非老年患者中的疗效和安全性问题，利用最近发表的两项试验数据，对新型选择性A型单胺氧化酶抑制剂溴法罗明和经典三环类药物丙咪嗪的差异效应进行了研究。我们发现，在疗效、不良发现的总发生率或实验室值和心率等安全参数方面，非老年和老年抑郁症患者之间没有重大差异。根据一些方法学问题和先前的报告对这些结果进行了讨论。
