RET/PTC oncogene activation is an early event in thyroid carcinogenesis.
作者信息
Viglietto G, Chiappetta G, Martinez-Tello F J, Fukunaga F H, Tallini G, Rigopoulou D, Visconti R, Mastro A, Santoro M, Fusco A
机构信息
Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Italy.
出版信息
Oncogene. 1995 Sep 21;11(6):1207-10.
RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas. However, it is not known yet whether it is an early or late event in the process of thyroid carcinogenesis. Here we demonstrate, by using a combined immunohistochemical and reverse transcriptase-polymerase chain reaction based approach, that RET/PTC activation is present in 11 out of 26 occult thyroid papillary carcinomas analysed. Therefore, we conclude that it represents an early event in the process of thyroid cell transformation.
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