Pellerito R, Agricola R, Giovanelli E, Neretto G
Arch Sci Med (Torino). 1978 Oct-Dec;135(4):485-92.
The relation between granulocyte turnover, as shown by serum lysozyme values, and the marrow granulocyte reserve, evaluated by means of the hydrocortisone test, was determined in 20 patients with metastasised solid tumours or lymphomas undergoing cytostatic and/or radiation management. In addition to confirming the validity of this test as a means of assessing the behaviour of the marrow storage compartment, it pointed to a correlation between the hydrocortisone test and serum lysozyme. High enzyme values, in fact, insofar as they are an expression of accelerated granulocyte turnover may be seen as an indication of reduced marrow function, and thus offer a simple means of predicting reduction of the marrow granulocyte reserve, and hence a possible post-chemotherapeutic leukopenia, in some cases where peripheral leukopenia is not apparent.
对20例接受细胞抑制和/或放射治疗的转移性实体瘤或淋巴瘤患者，测定了通过血清溶菌酶值所示的粒细胞周转率与通过氢化可的松试验评估的骨髓粒细胞储备之间的关系。除了证实该试验作为评估骨髓储存区行为手段的有效性外，还指出了氢化可的松试验与血清溶菌酶之间的相关性。事实上，高酶值作为粒细胞周转率加快的一种表现，可被视为骨髓功能降低的一个指标，因此在某些外周血白细胞减少不明显的情况下，提供了一种简单的方法来预测骨髓粒细胞储备的减少，进而预测可能出现的化疗后白细胞减少。
