老年人的狼疮抗凝物可能与奎宁和奎尼丁的使用都有关。

Lupus anticoagulant in the elderly may be associated with both quinine and quinidine usage.

作者信息

Bird M R, O'Neill A I, Buchanan R R, Ibrahim K M, Des Parkin J

机构信息

Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria.

出版信息

Pathology. 1995 Apr;27(2):136-9. doi: 10.1080/00313029500169742.

DOI:10.1080/00313029500169742

PMID:7567140

Abstract

Thirty-one patients aged over 60 yrs and with lupus anticoagulant (LA) were reviewed for their drug intake. Twenty-three (73%) were taking cinchona alkaloids, 10 (32%) quinine for night cramps, 11 (35%) quinidine for cardiac arrhythmia and 2 (6%) were taking both. These frequencies of drugs usage differed significantly from age and sex matched controls (p < 0.001). Five patients had features suggestive of the antiphospholipid syndrome. Repeat testing showed persistent LA activity in all but 2 of 5 patients in whom the relevant drug had been ceased. This is the first description of a possible causal association between LA and quinine therapy.

摘要

对31名年龄超过60岁且患有狼疮抗凝物质（LA）的患者的用药情况进行了回顾。23名（73%）患者正在服用金鸡纳生物碱，10名（32%）患者因夜间抽筋服用奎宁，11名（35%）患者因心律失常服用奎尼丁，2名（6%）患者同时服用两者。这些药物使用频率与年龄和性别匹配的对照组有显著差异（p<0.001）。5名患者具有抗磷脂综合征的特征。重复检测显示，在停止使用相关药物的5名患者中，除2名外，其余患者的LA活性持续存在。这是首次描述LA与奎宁治疗之间可能存在的因果关系。