Dombret H, Marolleau J P
Service Clinique des Maladies du Sang, Hôpital Saint Louis, Paris, France.
Nouv Rev Fr Hematol (1978). 1995;37(3):193-6.
Crohn's disease (CD) has been occasionally reported to be associated with myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML). From October 1991 to June 1993, four AML patients with a previous history of CD but no history of MDS were referred to our institution. Three presented AML with a monoblastic proliferation (one AML4 and two AML5). Cytogenetic analysis revealed a normal karyotype in two patients, an inv(16) in another and a del(11)(q24-25) in the fourth. Interestingly, the three patients with AML4/AML5 had not received high doses of immunosuppressive agents, prior CD therapy ranging from 1 to 4 months sulfasalazine with additional azathioprine in one case.
克罗恩病（CD）偶尔被报道与骨髓增生异常综合征（MDS）或急性髓系白血病（AML）有关。1991年10月至1993年6月，4例既往有CD病史但无MDS病史的AML患者被转诊至我院。3例表现为AML伴单核细胞增生（1例AML4和2例AML5）。细胞遗传学分析显示，2例患者核型正常，另1例为inv(16)，第4例为del(11)(q24 - 25)。有趣的是，3例AML4/AML5患者未接受过高剂量免疫抑制剂治疗，之前的CD治疗包括1至4个月的柳氮磺胺吡啶，其中1例加用了硫唑嘌呤。
