• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis of 3H-labeled nucleoside-methyl[CT3]phosphonamidite and incorporation into methylphosphonate oligonucleotides for biodistribution and biostability studies.

作者信息

Vaghefi M M, Fazio R C, Young K M, Marvin W B

机构信息

Genta Inc., San Diego, CA 92121, USA.

出版信息

Nucleic Acids Res. 1995 Sep 11;23(17):3600-2. doi: 10.1093/nar/23.17.3600.

DOI:10.1093/nar/23.17.3600
PMID:7567475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC307243/
Abstract
摘要

相似文献

1
Synthesis of 3H-labeled nucleoside-methyl[CT3]phosphonamidite and incorporation into methylphosphonate oligonucleotides for biodistribution and biostability studies.用于生物分布和生物稳定性研究的3H标记的核苷-甲基[CT3]亚磷酰胺的合成及其掺入甲基膦酸酯寡核苷酸中。
Nucleic Acids Res. 1995 Sep 11;23(17):3600-2. doi: 10.1093/nar/23.17.3600.
2
Oligonucleotide synthesis. Phosphotriester approach.
Methods Mol Biol. 1993;20:19-31. doi: 10.1385/0-89603-281-7:19.
3
Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages.含甲基膦酸酯键的修饰寡脱氧核苷酸的细胞摄取机制。
Nucleic Acids Res. 1991 Oct 25;19(20):5543-50. doi: 10.1093/nar/19.20.5543.
4
3'-modified oligonucleotides by reverse DNA synthesis.通过反向DNA合成的3'修饰寡核苷酸。
Nucleic Acids Res. 2003 Oct 1;31(19):5685-91. doi: 10.1093/nar/gkg734.
5
Synthetic strategies and parameters involved in the synthesis of oligodeoxyribonucleotides according to the phosphoramidite method.根据亚磷酰胺法合成寡脱氧核糖核苷酸所涉及的合成策略和参数。
Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 3:Unit 3.3. doi: 10.1002/0471142700.nc0303s00.
6
Nucleoside-O-Methyl-(H)-Phosphinates: Novel Monomers for the Synthesis of Methylphosphonate Oligonucleotides Using H-Phosphonate Chemistry.核苷 - O - 甲基 -（氢）- 次膦酸酯：使用氢膦酸酯化学合成甲基膦酸酯寡核苷酸的新型单体。
Curr Protoc Nucleic Acid Chem. 2017 Sep 18;70:4.76.1-4.76.22. doi: 10.1002/cpnc.35.
7
Synthesis of a convenient thymidine glycol phosphoramidite monomer and its site-specific incorporation into DNA fragments.一种便捷的胸苷二醇亚磷酰胺单体的合成及其位点特异性掺入DNA片段
Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1831-42. doi: 10.1080/15257770500267279.
8
The 4-methylthio-1-butyl group for phosphate/thiophosphate protection in oligodeoxyribonucleotide synthesis.用于寡脱氧核糖核苷酸合成中磷酸酯/硫代磷酸酯保护的4-甲硫基-1-丁基基团。
Curr Protoc Nucleic Acid Chem. 2004 Dec;Chapter 3:Unit 3.11. doi: 10.1002/0471142700.nc0311s19.
9
A new coupling method for the synthesis of oligodeoxyribonucleotides based on protection by protonation of nucleoside bases.一种基于核苷酸碱基质子化保护作用合成寡脱氧核糖核苷酸的新偶联方法。
Nucleic Acids Res Suppl. 2001(1):77-8. doi: 10.1093/nass/1.1.77.
10
Linker phosphoramidite reagents for the attachment of the first nucleoside to underivatized solid-phase supports.用于将第一个核苷连接到未衍生化固相载体上的连接子亚磷酰胺试剂。
Nucleic Acids Res. 2004 Jan 29;32(2):623-31. doi: 10.1093/nar/gkh222. Print 2004.

引用本文的文献

1
Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages.含手性纯R(P)甲基膦酸酯键的寡核苷酸的合成与热力学
Nucleic Acids Res. 1996 Nov 15;24(22):4584-91. doi: 10.1093/nar/24.22.4584.

本文引用的文献

1
Deprotection of methylphosphonate oligonucleotides using a novel one-pot procedure.使用一种新型一锅法对甲基膦酸酯寡核苷酸进行脱保护。
Nucleic Acids Res. 1993 May 11;21(9):2031-8. doi: 10.1093/nar/21.9.2031.
2
Current concepts in antisense drug design.反义药物设计的当前概念。
J Med Chem. 1993 Jul 9;36(14):1923-37. doi: 10.1021/jm00066a001.
3
An improved method for the synthesis and deprotection of methylphosphonate oligonucleotides.一种用于合成和脱保护甲基膦酸酯寡核苷酸的改进方法。
Methods Mol Biol. 1993;20:143-64. doi: 10.1385/0-89603-281-7:143.
4
Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate.体内3H标记寡核苷酸的生物分布与代谢。I. 磷酸二酯和硫代磷酸酯的比较。
Mol Pharmacol. 1994 May;45(5):932-43.
5
Development of antisense therapeutics. Implications for cancer gene therapy.反义疗法的发展。对癌症基因治疗的启示。
Ann N Y Acad Sci. 1994 May 31;716:228-41. doi: 10.1111/j.1749-6632.1994.tb21715.x.
6
Applications of antisense oligonucleotides in oncology.反义寡核苷酸在肿瘤学中的应用。
Cell Mol Biol (Noisy-le-grand). 1994 May;40(3):237-61.
7
Disposition and metabolism of oligodeoxynucleoside methylphosphonate following a single i.v. injection in mice.小鼠单次静脉注射后甲基膦酸寡脱氧核苷的处置与代谢。
Drug Metab Dispos. 1990 Sep-Oct;18(5):815-8.
8
Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.硫代磷酸寡脱氧核苷酸在小鼠体内的药代动力学、生物分布及稳定性
Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7595-9. doi: 10.1073/pnas.88.17.7595.
9
Organ distribution and stability of phosphorothioated oligodeoxyribonucleotides in mice.硫代磷酸化寡脱氧核糖核苷酸在小鼠体内的器官分布及稳定性
Biopharm Drug Dispos. 1992 Apr;13(3):221-7. doi: 10.1002/bdd.2510130308.
10
Antisense oligonucleotides: inhibition of liver cell proliferation and in vivo disposition.反义寡核苷酸：对肝细胞增殖的抑制作用及体内处置
Transplant Proc. 1992 Dec;24(6):2971-2.