Synthesis of 3H-labeled nucleoside-methyl[CT3]phosphonamidite and incorporation into methylphosphonate oligonucleotides for biodistribution and biostability studies.
作者信息
Vaghefi M M, Fazio R C, Young K M, Marvin W B
机构信息
Genta Inc., San Diego, CA 92121, USA.
出版信息
Nucleic Acids Res. 1995 Sep 11;23(17):3600-2. doi: 10.1093/nar/23.17.3600.
Abstract
摘要
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Nucleic Acids Res. 1993 May 11;21(9):2031-8. doi: 10.1093/nar/21.9.2031.
2
Current concepts in antisense drug design.反义药物设计的当前概念。
J Med Chem. 1993 Jul 9;36(14):1923-37. doi: 10.1021/jm00066a001.
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An improved method for the synthesis and deprotection of methylphosphonate oligonucleotides.一种用于合成和脱保护甲基膦酸酯寡核苷酸的改进方法。
Methods Mol Biol. 1993;20:143-64. doi: 10.1385/0-89603-281-7:143.
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Development of antisense therapeutics. Implications for cancer gene therapy.反义疗法的发展。对癌症基因治疗的启示。
Ann N Y Acad Sci. 1994 May 31;716:228-41. doi: 10.1111/j.1749-6632.1994.tb21715.x.
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Applications of antisense oligonucleotides in oncology.反义寡核苷酸在肿瘤学中的应用。
Cell Mol Biol (Noisy-le-grand). 1994 May;40(3):237-61.
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Disposition and metabolism of oligodeoxynucleoside methylphosphonate following a single i.v. injection in mice.小鼠单次静脉注射后甲基膦酸寡脱氧核苷的处置与代谢。
Drug Metab Dispos. 1990 Sep-Oct;18(5):815-8.
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