Borges M M, Vassao R, Andrade S G, Pereira C A, Kloetzel J K
Instituto de Medicina Tropical de São Paulo, Brazil.
Parasitol Res. 1995;81(6):498-504. doi: 10.1007/BF00931793.
Serum levels of interferon-gamma (IFN-gamma) were evaluated in Calomys callosus and Swiss mice during the course of infection by four strains of Trypanosoma cruzi. All strains stimulated the production of this interleukine; however, the timing of its onset and permanence varied among strains and between the two animal models. When chronically infected animals with no detectable serum IFN-gamma were challenged with the homologous strain, they produced quantities comparable with those obtained during the acute phase of infection. In C. callosus there was a correlation between H2O2 liberation by peritoneal macrophages and serum IFN-gamma levels, whereas no such correlation was found in mice. C. callosus had a higher capacity to heal histopathological lesions, whereas lesions in mice were progressive. The results obtained suggest that C. callosus develops well-adapted immune mechanisms that may be important for its role as a reservoir of T. cruzi.
在粗尾棉鼠（Calomys callosus）和瑞士小鼠感染四种克氏锥虫（Trypanosoma cruzi）的过程中，对血清中的γ-干扰素（IFN-γ）水平进行了评估。所有菌株均刺激了这种白细胞介素的产生；然而，其出现的时间和持续时间在不同菌株之间以及两种动物模型之间有所不同。当用同源菌株对血清中未检测到IFN-γ的慢性感染动物进行攻击时，它们产生的量与在感染急性期获得的量相当。在粗尾棉鼠中，腹膜巨噬细胞释放H2O2与血清IFN-γ水平之间存在相关性，而在小鼠中未发现这种相关性。粗尾棉鼠愈合组织病理学损伤的能力更强，而小鼠的损伤则呈进行性发展。所获得的结果表明，粗尾棉鼠发展出了适应性良好的免疫机制，这可能对其作为克氏锥虫储存宿主的作用很重要。
