Suzuki M, Yagi N, Gerstein M
MRC Laboratory of Molecular Biology, Cambridge, UK.
Protein Eng. 1995 Apr;8(4):329-38. doi: 10.1093/protein/8.4.329.
The way helix-turn-helix proteins recognize DNA is analysed by comparing their sequences, structures, and binding specificities. Individual recognition helices in these proteins bind to four DNA base pairs with the same geometry. However, pairs of recognition helices in the protein dimers can have different separations and orientations. These differences are used for discriminating between DNAs which have different superstructures, in particular, different numbers of base pairs between sets of the four base pairs.
通过比较螺旋-转角-螺旋蛋白的序列、结构和结合特异性，分析了它们识别DNA的方式。这些蛋白中的单个识别螺旋以相同的几何结构与四个DNA碱基对结合。然而，蛋白二聚体中的识别螺旋对可以有不同的间距和方向。这些差异被用于区分具有不同超结构的DNA，特别是四个碱基对集合之间具有不同数量碱基对的DNA。
