锌指对DNA识别的立体化学基础。
Stereochemical basis of DNA recognition by Zn fingers.
作者信息
Suzuki M, Gerstein M, Yagi N
机构信息
MRC Laboratory of Molecular Biology, Cambridge, UK.
出版信息
Nucleic Acids Res. 1994 Aug 25;22(16):3397-405. doi: 10.1093/nar/22.16.3397.
Abstract
DNA-recognition rules for Zn fingers are discussed in terms of crystal structures. The rules can explain the DNA-binding characteristics of a number of Zn finger proteins for which there are no crystal structures. The rules have two parts: chemical rules, which list the possible pairings between the 4 DNA bases and the 20 amino acid residues, and stereochemical rules, which describe the specific base positions contacted by several amino acid positions in the Zn finger. It is discussed that to maintain the correct binding geometry, in which the N-terminus of the recognition helix is closer to the DNA than the C-terminus, the residues facing the DNA on the helix must be larger near the C-terminus, and that two different types of fingers (A and B) bind to DNA in distinctly different ways and cover different numbers of base pairs.
摘要
根据晶体结构讨论了锌指的DNA识别规则。这些规则可以解释许多没有晶体结构的锌指蛋白的DNA结合特性。这些规则有两部分：化学规则，列出了4种DNA碱基与20种氨基酸残基之间可能的配对；立体化学规则，描述了锌指中几个氨基酸位置所接触的特定碱基位置。讨论了为保持正确的结合几何结构（其中识别螺旋的N端比C端更靠近DNA），螺旋上面对DNA的残基在C端附近必须更大，并且两种不同类型的指（A和B）以截然不同的方式结合到DNA上并覆盖不同数量的碱基对。
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