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小鼠Col18a1以三种可变变体的形式以组织特异性方式表达，并定位于基底膜区域。

Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones.

作者信息

Muragaki Y, Timmons S, Griffith C M, Oh S P, Fadel B, Quertermous T, Olsen B R

机构信息

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8763-7. doi: 10.1073/pnas.92.19.8763.

DOI:10.1073/pnas.92.19.8763
PMID:7568013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC41047/
Abstract

We have isolated overlapping cDNAs encoding the N-terminal non-triple-helical region of mouse alpha 1(XVIII) collagen and shown that three different variants of alpha 1(XVIII) collagen exist. Each of the three variants shows characteristic tissue-specific expression patterns. Immunohistochemical studies show positive staining for alpha 1(XVIII) collagen along the basement membrane zones of vessels in the intestinal villi, the choroid plexus, skin, liver, and kidney. Thus, we conclude that alpha 1(XVIII) collagen may interact (directly or indirectly) with components in basement membrane zones or on the basal surface of endothelial/epithelial cells.

摘要

我们分离出了编码小鼠α1（XVIII）胶原蛋白N端非三螺旋区域的重叠cDNA，并证明存在三种不同的α1（XVIII）胶原蛋白变体。这三种变体中的每一种都显示出特征性的组织特异性表达模式。免疫组织化学研究表明，α1（XVIII）胶原蛋白在肠绒毛、脉络丛、皮肤、肝脏和肾脏的血管基底膜区域呈阳性染色。因此，我们得出结论，α1（XVIII）胶原蛋白可能与基底膜区域或内皮/上皮细胞基底表面的成分（直接或间接）相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/839120a7a280/pnas01497-0244-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/659c83a72f16/pnas01497-0240-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/d9fafecc7a97/pnas01497-0242-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/4a1d4171ff55/pnas01497-0243-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/d116da2d4a79/pnas01497-0243-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/839120a7a280/pnas01497-0244-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/659c83a72f16/pnas01497-0240-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/d9fafecc7a97/pnas01497-0242-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/4a1d4171ff55/pnas01497-0243-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/d116da2d4a79/pnas01497-0243-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6076/41047/839120a7a280/pnas01497-0244-a.jpg

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7
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Genomics. 1994 Feb;19(3):494-9. doi: 10.1006/geno.1994.1098.
8
Alpha 1(XVIII), a collagen chain with frequent interruptions in the collagenous sequence, a distinct tissue distribution, and homology with type XV collagen.α1（XVIII），一种在胶原序列中频繁中断、具有独特组织分布且与XV型胶原具有同源性的胶原链。
Proc Natl Acad Sci U S A. 1994 May 10;91(10):4234-8. doi: 10.1073/pnas.91.10.4234.
9
Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins.对具有多个Gly-Xaa-Yaa重复结构域的蛋白质的cDNA进行分离和测序，鉴定出一个独特的胶原质蛋白质家族。
Proc Natl Acad Sci U S A. 1994 May 10;91(10):4229-33. doi: 10.1073/pnas.91.10.4229.
10
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J Biol Chem. 1995 Mar 3;270(9):4705-11. doi: 10.1074/jbc.270.9.4705.