Anderson J, Gordon E, Barry R J, Rennie C, Gonsalvez C, Pettigrew G, Beumont P J, Meares R
Department of Psychiatry, Westmead Hospital, NSW, Australia.
Psychiatry Res. 1995 Apr 28;56(3):237-43. doi: 10.1016/0165-1781(95)02557-d.
The response-variance-curve (RVC) method quantifies the variability of the individual epochs that constitute the average event related potential (ERP), providing complementary information to that offered by ERPs. Numerous studies have found that average ERP late components of an auditory "oddball" paradigm can differentiate schizophrenic patients from normal subjects. Our previous study of the RVC measure revealed significant differences between medicated and unmedicated schizophrenic patients in the maximum ERP variability from 190 to 240 ms. In the present study of unmedicated schizophrenic patients and normal control subjects, we examined the influence of intertarget intervals (generated by pseudorandom stimulus sequences in an auditory oddball paradigm) on the intratrial effects of ERP variability measured by the RVC. The ERPs of unmedicated schizophrenic patients were characterized by an instability in a latency window corresponding to the N200 component. The effect was particularly large at an intertarget interval of 7.8 s and was significantly reduced on either side of this intertarget interval.
反应方差曲线（RVC）方法量化了构成平均事件相关电位（ERP）的各个 epoch 的变异性，为 ERP 提供的信息提供了补充。大量研究发现，听觉“oddball”范式的平均 ERP 晚期成分可以区分精神分裂症患者和正常受试者。我们之前对 RVC 测量的研究表明，服药和未服药的精神分裂症患者在 190 至 240 毫秒的最大 ERP 变异性方面存在显著差异。在本研究中，我们对未服药的精神分裂症患者和正常对照受试者进行了研究，考察了听觉 oddball 范式中伪随机刺激序列产生的目标间间隔对 RVC 测量的 ERP 变异性的试验内效应的影响。未服药的精神分裂症患者的 ERP 特征是在对应于 N200 成分的潜伏期窗口内不稳定。这种效应在目标间间隔为 7.8 秒时尤为明显，在该目标间间隔的两侧则显著降低。
