Anderson J, Gordon E, Barry R J, Rennie C, Beumont P J, Meares R
Department of Psychiatry, University of Sydney, Westmead Hospital, NSW, Australia.
Psychiatry Res. 1995 Apr 28;56(3):229-36. doi: 10.1016/0165-1781(95)02556-c.
The averaging of individual late component event related potential (ERP) responses, particularly P300, has revealed significant differences between schizophrenic patients and normal subjects. However, the averaging process removes the variability of the individual epochs that constitute that average. The response-variance-curve (RVC) method quantifies the variability of the individual epochs and allows examinations of windows of maximum variance. In this study, we examine the complementary nature of the RVC method to the traditional averaging approach. The averaged N200 and P300 ERP components differed significantly between the schizophrenic and normal groups, but not between the unmedicated and medicated schizophrenic patients. The RVC measure, on the other hand, revealed systematic differences in variability, maximal between 190 and 240 ms, between the unmedicated and medicated schizophrenic patients. The RVC measure therefore provides a focused time frame in which to examine dysfunctions in information processing and macroscopic scale changes in brain function due to medication.
对个体晚期成分事件相关电位（ERP）反应，尤其是P300进行平均，已揭示出精神分裂症患者与正常受试者之间存在显著差异。然而，平均过程消除了构成该平均值的各个时段的变异性。反应方差曲线（RVC）方法量化了各个时段的变异性，并允许对最大方差窗口进行检查。在本研究中，我们考察了RVC方法与传统平均方法的互补性质。精神分裂症组与正常组之间，平均N200和P300 ERP成分存在显著差异，但未用药的精神分裂症患者与用药的精神分裂症患者之间无显著差异。另一方面，RVC测量显示，未用药的精神分裂症患者与用药的精神分裂症患者之间在变异性上存在系统性差异，最大差异出现在190至240毫秒之间。因此，RVC测量提供了一个聚焦的时间框架，用于检查信息处理功能障碍以及药物治疗导致的大脑功能宏观尺度变化。
