Rubin E, Sackeim H A, Prohovnik I, Moeller J R, Schnur D B, Mukherjee S
New York State Psychiatric Institute, NY 10032, USA.
Psychiatry Res. 1995 May 31;61(1):1-10. doi: 10.1016/0925-4927(95)02594-n.
Cortical regional cerebral blood flow (rCBF) was assessed in minimally medicated, relatively young adults in episodes of either acute mania (n = 11) or major depression (n = 11) and in matched normal control subjects (n = 11), using the 133xenon inhalation method, under eyes-closed, resting conditions. The three groups were equivalent in global CBF. Both patient groups showed significant reductions of rCBF in anterior cortical areas and reduction of the normal anteroposterior gradient. In addition, there was evidence of abnormal, albeit similar, patterns of flow lateralization on a regional basis in both clinical groups compared with normal subjects. An exploratory analysis revealed preliminary evidence of rCBF differences between the clinical groups, localized to the inferior frontal cortex. Otherwise, the evidence in this study suggests that young adult manic and depressed patients are predominantly similar in cortical rCBF parameters.
采用氙-133吸入法，在闭眼静息状态下，对用药量极少的相对年轻的成年人进行研究，评估其在急性躁狂发作期（n = 11）或重度抑郁发作期（n = 11）以及匹配的正常对照受试者（n = 11）的皮质局部脑血流量（rCBF）。三组的全脑血流量相当。两个患者组均显示前皮质区域的rCBF显著降低，且正常的前后梯度减小。此外，与正常受试者相比，两个临床组在区域基础上均存在异常但相似的血流侧化模式。一项探索性分析揭示了临床组之间rCBF差异的初步证据，定位于额下回皮质。否则，本研究的证据表明，年轻的躁狂和抑郁患者在皮质rCBF参数方面主要相似。
