Görich J, Hasan I, Majdali R, Sittek H, Kunze V, Doma A, Reiser M, Brambs H J
Department of Radiology I, Universitätsklinik Ulm, Germany.
Radiology. 1995 Oct;197(1):199-203. doi: 10.1148/radiology.197.1.7568824.
To evaluate the effectiveness of intraarterial infusion chemotherapy (IAC) with mitoxantrone hydrochloride in patients with previously treated, locally recurrent breast cancer.
Thirty-nine women (aged 31-82 years) with recurrent breast cancer underwent superselective IAC (25 mg/m2 mitoxantrone hydrochloride every 24 hours) through the subclavian artery branches after heparin administration. The extent of tumor perfusion was monitored with computed tomography during the intraarterial administration of contrast medium. IAC was repeated one to nine times. Patients had previously undergone radiation therapy (n = 39), surgery (n = 20), or systemic chemotherapy (n = 23).
The overall response rate was 77% (n = 30). Eight patients had complete remission. Progression occurred in three patients. Remission was observed in cases of lymph node involvement (n = 9). Seven patients are still undergoing treatment. Side effects were usually moderate. Nine patients died of systemic tumor spread. In 14 patients, distant metastases developed during the first 18 months of treatment.
IAC is an effective, well-tolerated therapy in patients with locally recurrent breast cancer.
评估盐酸米托蒽醌动脉内灌注化疗（IAC）对既往接受过治疗的局部复发性乳腺癌患者的疗效。
39例（年龄31 - 82岁）复发性乳腺癌女性患者在给予肝素后，通过锁骨下动脉分支接受超选择性IAC（每24小时给予盐酸米托蒽醌25mg/m²）。在动脉内注射造影剂期间，用计算机断层扫描监测肿瘤灌注程度。IAC重复1至9次。患者先前均接受过放射治疗（n = 39）、手术（n = 20）或全身化疗（n = 23）。
总缓解率为77%（n = 30）。8例患者完全缓解。3例患者病情进展。在有淋巴结受累的病例中观察到缓解（n = 9）。7例患者仍在接受治疗。副作用通常为中度。9例患者死于全身肿瘤扩散。14例患者在治疗的前18个月内出现远处转移。
IAC是局部复发性乳腺癌患者一种有效且耐受性良好的治疗方法。
