Görich J, Hasan I, Sittek H, Jakschik J, Werner H, Hartlapp H J, Reiser M
Radiologische Klinik, Universität Bonn.
Radiologe. 1993 May;33(5):308-12.
Forty-two patients with locally advanced breast cancer (n = 8) or recurrent breast cancer (n = 34) received regional chemotherapy (mitoxantrone 25 mg/m2 per 24 h) via the internal mammary artery or other vessels of the subclavian artery. To prevent artery thrombosis 500-1000 U heparin per hour were administered i.v. Tumour perfusion was monitored by intra-arterial angio-CT. Remission rates (CR + PR) were 100% (primary breast cancer) and 89% (recurrent tumours), respectively. Intra-arterial chemotherapy was well tolerated. No complications were noted.
42例局部晚期乳腺癌患者（n = 8）或复发性乳腺癌患者（n = 34）通过内乳动脉或锁骨下动脉的其他血管接受了区域化疗（米托蒽醌25 mg/m²，每24小时一次）。为预防动脉血栓形成，每小时静脉注射500 - 1000 U肝素。通过动脉内血管CT监测肿瘤灌注情况。缓解率（CR + PR）分别为100%（原发性乳腺癌）和89%（复发性肿瘤）。动脉内化疗耐受性良好。未观察到并发症。
