Müller M, Brem G
Veterinärmedizinische Universität Wien, Institut für Tierzucht und Genetik, Austria.
Reprod Fertil Dev. 1994;6(5):605-13. doi: 10.1071/rd9940605.
Approaches to modify disease resistance or susceptibility by transgenic means will be a major asset to animal welfare as well as to the economics of animal production. Candidates for gene transfer experiments include all genes known to influence non-specific and specific host defence mechanisms against infectious pathogens. Additional strategies such as 'intracellular immunization', 'genetic and congenital immunization', antisense RNA approaches and targeted disruption of disease susceptibility genes promise to gain importance in conferring increased disease resistance. The cytokine network regulates cellular viability, growth and differentiation in physiological and pathophysiological states. Detailed understanding of cytokine signal transduction pathways and transcriptional activators will provide not only new target molecules for modulating the immune response but will also facilitate the elucidation of host-pathogen interactions.
通过转基因手段改变抗病性或易感性的方法，对于动物福利以及动物生产的经济性而言将是一项重要资产。基因转移实验的候选基因包括所有已知影响宿主针对传染性病原体的非特异性和特异性防御机制的基因。诸如“细胞内免疫”“遗传和先天性免疫”、反义RNA方法以及对疾病易感基因的靶向破坏等其他策略，有望在增强抗病性方面变得更加重要。细胞因子网络在生理和病理生理状态下调节细胞活力、生长和分化。对细胞因子信号转导途径和转录激活因子的详细了解，不仅将为调节免疫反应提供新的靶分子，还将有助于阐明宿主与病原体之间的相互作用。
